Chen Li
University of Cambridge
Genome-wide association studyCancerTelomereDiseaseThyroid cancerMendelian randomizationGeneticsMedical geneticsBiomarker (medicine)Biology
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#1Chen Li (University of Cambridge)H-Index: 1
#2Svetlana Stoma (University of Leicester)H-Index: 1
Last. Veryan Codd (University of Leicester)H-Index: 30
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Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) 350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, l...
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