Jiwei Sun
Huazhong University of Science and Technology
GeneGene silencingCircadian rhythmCancerEndothelial stem cellDownregulation and upregulationCellRegulation of gene expressionBone remodelingEndochondral ossificationIntramembranous ossificationMesenchymal stem cellImmunologyIn vivoOxidative stressOsteoarthritisOsteoporosisHead and neck squamous-cell carcinomaSubcellular localizationInflammationEndotheliumCarcinomaNF-?BPER2Tumor progressionPorphyromonas gingivalisCartilageEndothelial dysfunctionTissue migrationExtracellular matrix bindingCancer researchCell growthHomeostasisBone resorptionMedicineEpithelial–mesenchymal transitionCell cultureBiologyCell biology
5Publications
3H-index
22Citations
Publications 7
Newest
#1Jiwei Sun (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Qingming Tang (HUST: Huazhong University of Science and Technology)H-Index: 8
Last. Lili Chen (HUST: Huazhong University of Science and Technology)H-Index: 14
view all 0 authors...
Source
#1Jinfeng Peng (TJMC: Tongji Medical College)H-Index: 2
#2Jiwei Sun (TJMC: Tongji Medical College)H-Index: 3
Last. Lili Chen (TJMC: Tongji Medical College)H-Index: 14
view all 0 authors...
Background null SARS-CoV-2, which has brought a huge negative impact on the world since the end of 2019, is reported to invade cells using the spike (S) protein to bind to angiotensin-converting enzyme II (ACE2) receptors on human cells while the transmembrane protease serine 2 (TMPRSS2) is the key protease that activates the S protein, which greatly facilitates the entry of SARS-CoV-2 into target cells. In our previous study, it was observed that the positive rate of SARS-CoV-2 nucleic acids in...
Source
#1Guangjin Chen (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Jiwei Sun (HUST: Huazhong University of Science and Technology)H-Index: 3
Last. Lili Chen (HUST: Huazhong University of Science and Technology)H-Index: 14
view all 6 authors...
Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. However, the biological functions and potential mechanisms of PLAU in head and neck squamous cell carcinoma (HNSCC) remain undetermined. Here, the expression, prognosis, function, and coexpression genetic networks of PLAU in HNSCC were investigated by a series of public bioinformatics tools. A Higher PLAU level predicted a poorer clinical outcome. Meanwhile, functiona...
Source
#1Mengru Xie (HUST: Huazhong University of Science and Technology)H-Index: 6
#2Qingming Tang (HUST: Huazhong University of Science and Technology)H-Index: 8
Last. Lili Chen (HUST: Huazhong University of Science and Technology)H-Index: 14
view all 7 authors...
Cardiovascular disease is still the leading cause of mortality worldwide. Vascular endothelial dysfunction is viewed as the initial step of most cardiovascular diseases. Many studies have indicated that periodontal pathogens, especially Porphyromonas gingivalis, are closely correlated with vascular endothelial homeostasis, but the function of P. gingivalis and the underlying mechanisms are still elusive. To illuminate the effects and elucidate the mechanisms of P. gingivalis on endothelial struc...
11 CitationsSource
#1Guangjin Chen (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Qingming Tang (HUST: Huazhong University of Science and Technology)H-Index: 8
Last. Lili Chen (HUST: Huazhong University of Science and Technology)H-Index: 14
view all 7 authors...
BMAL1 is a core component of the circadian clock loop, which directs the sophisticated circadian expression of clock-controlled genes. Skeletal Bone development is a complex biological process involving intramembranous ossification, endochondral ossification and bone remodeling, as well as specific cells, such as mesenchymal cells, osteoblasts, osteoclasts, chondrocytes, etc. Growing evidences suggest that BMAL1 is indispensable for hard tissue development, including bone, cartilage and teeth. L...
4 CitationsSource
#1Mengru Xie (HUST: Huazhong University of Science and Technology)H-Index: 6
#2Qingming Tang (HUST: Huazhong University of Science and Technology)H-Index: 8
Last. Lili Chen (HUST: Huazhong University of Science and Technology)H-Index: 14
view all 11 authors...
Rationale: Atherosclerotic cardiovascular diseases (ACVDs) are the leading cause of mortality worldwide. ACVDs are considered as chronic inflammation processes. In addition to risk factors associat...
14 CitationsSource
#1Fengyuan Guo (WHU: Wuhan University)H-Index: 2
#2Qingming Tang (HUST: Huazhong University of Science and Technology)H-Index: 8
Last. Wen-Feng Zhang (WHU: Wuhan University)H-Index: 33
view all 7 authors...
Oral squamous cell carcinoma, one of the most prevalent cancer types in the world, has been confirmed under the influence of a key circadian gene, PER2, whose role has been identified in the development of some other types of cancers. However, the mechanism through which PER2 regulates the progress of OSCC remains largely unknown. In this study, we showed that besides the abnormal expression and subcellular localization of PER2 observed in OSCC tissues and cells as expected, these anomalous chan...
2 CitationsSource