Ryoichi Mori
University of Bristol
NeuriteActinDownregulation and upregulationCell migrationPathologyEmbryonic stem cellCellFocal adhesionMolecular biologyEphrinChemistryExtracellular matrixSkin repairAdherens junctionImmunologyMyofibroblastPerlecanGranulation tissueInflammationKeratinocyteLungAcetylcholinesteraseBlood cellWound healingFibroblastFibrosisOsteopontinStress fiberPulmonary fibrosisPlatelet-derived growth factorFibroblast migrationAmyloid precursor proteinCancer researchSignal transductionMedicineCell cultureBiologyCell biology
Publications 5
#1Robert Nunan (UoB: University of Bristol)H-Index: 3
#2Jessica Campbell (UoB: University of Bristol)H-Index: 3
Last. Paul Martin (UoB: University of Bristol)H-Index: 78
view all 9 authors...
For a skin wound to successfully heal, the cut epidermal-edge cells have to migrate forward at the interface between scab and healthy granulation tissue. Much is known about how lead-edge cells migrate, but very little is known about the mechanisms that enable active participation by cells further back. Here we show that ephrin-B1 and its receptor EphB2 are both upregulated in vivo, just for the duration of repair, in the first 70 or so rows of epidermal cells, and this signal leads to downregul...
#1Alexandra Anderson (Imperial College London)H-Index: 9
#2Dmitry S. Ushakov (NIH: National Institutes of Health)H-Index: 15
Last. Jane L. Saffell (Imperial College London)H-Index: 6
view all 6 authors...
Acetylcholinesterase (AChE) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. It is widely expressed outside the nervous system, but its function in non-neuronal cells is unclear. Here we have investigated the distribution and function of AChE in fibroblasts and astrocytes. We show that these cells express high levels of AChE protein that co-migrates with reco...
#1Ryoichi Mori (UoB: University of Bristol)H-Index: 5
#2Tanya J. ShawH-Index: 17
Last. Paul Martin (UoB: University of Bristol)H-Index: 78
view all 3 authors...
Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis. In a series of in vitro and in vivo studies, we analyze the effects of blocking OPN expression at the wound, and determine which inflammatory cells, and which paracrine factors from these cells, may be responsible for triggering OPN expression in wound fibroblasts. Delivery of OPN anti...
#1Brian Stramer (UoB: University of Bristol)H-Index: 22
#2Ryoichi Mori (UoB: University of Bristol)H-Index: 5
Last. Paul Martin (UoB: University of Bristol)H-Index: 78
view all 3 authors...
The healing of a skin wound is a complex process involving many cell lineages. In adult tissues, repair is always accompanied by a robust inflammatory response, which is necessary to counter the potential for infection at any site where the skin barrier is breached. Unlike embryonic tissues that can repair perfectly without a remnant scar at the wound site, adult tissue repair always leads to formation of a fibrotic scar where the wound has healed. In recent years, it has become clear that the w...
#1Ryoichi Mori (UoB: University of Bristol)H-Index: 5
#2Kieran T. PowerH-Index: 2
Last. David L. BeckerH-Index: 51
view all 5 authors...
Experimental downregulation of connexin43 (Cx43) expression at skin wound sites appears to markedly improve the rate and quality of healing, but the underlying mechanisms are currently unknown. Here, we have compared physiological and cell biological aspects of the repair process with and without Cx43 antisense oligodeoxynucleotide treatment. Treated wounds exhibited accelerated skin healing with significantly increased keratinocyte and fibroblast proliferation and migration. In vitro knockdown ...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.