Alessandro Gambella
University of Turin
Loss functionDeep learningAlgorithmInterquartile rangeCancerImage segmentationInternal medicineRadiologyPathologyUltrasoundOncologyPerfusionSerous fluidLogistic regressionCell-free fetal DNAArtificial intelligenceOdds ratioRetrospective cohort studyPattern recognitionStage (cooking)CytologyHuman leukocyte antigenProspective cohort studyUnivariateImmunohistochemistryNoninvasive follicular thyroid neoplasm with papillary-like nuclear featuresBiopsyTeratomaOrbit (anatomy)ProstateChemotherapyPerformance statusSynaptophysinLactate dehydrogenaseGlomerulosclerosisDigital pathologyGliomaPancreasNodule (medicine)MetastasisThyroid nodulesNeuroendocrine tumorsMachine perfusionLiver transplantationEosinophilicContext (language use)KidneySurgical oncologyProstate cancerPrimary tumorKidney transplantationEndoscopic ultrasoundOvarian cancerAcute kidney injuryFibrosisDifferential diagnosisCaveolin 1HLA-DRB1LesionKRASNephronStainFibrin glueMacrovesicular steatosisNodular lymphoid hyperplasiaMitotic CountCystic teratomaOncocytic changesPulmonary nodular lymphoid hyperplasiaGenetic profilePulmonary Lymphoid HyperplasiaTubular atrophyHLA MismatchRadical excisionGastrointestinal stromal tumoursHodgkin lymphomaLiver surgeryRenal fibrosisThyroid carcinomaProstate glandGene mutationRelapse rateAutomated algorithmSurgical approachHistological examinationRisk of malignancyAutomated segmentationSurgical treatmentOverall survivalImatinib treatmentRetrospective analysisExtended criteriaGraft survivalFully automatedPDGFRAGold standard (test)Computer scienceConfidence intervalDigital polymerase chain reactionPolymerase chain reactionCancer researchRadiation therapyThyroidColorectal cancerCentral nervous systemNervous systemCarcinogenesisMedicineCohortMolecular pathologyBiomarker (medicine)Chromogranin AComplicationBiologySegmentationGastroenterologyNeurotrophin
21Publications
4H-index
48Citations
Publications 19
Newest
#1Nicola De Stefano (UNITO: University of Turin)H-Index: 2
#2Victor Navarro-Tableros (UNITO: University of Turin)H-Index: 6
Last. Damiano Patrono (UNITO: University of Turin)H-Index: 17
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Livers from donors after circulatory death (DCD) are a promising option to increase the donor pool, but their use is associated with higher complication rate and inferior graft survival. Normothermic machine perfusion (NMP) keeps the graft at 37°C, providing nutrients and oxygen supply. Human liver stem cell-derived extracellular vesicles (HLSC-EVs) are able to reduce liver injury and promote regeneration. We investigated the efficacy of a reconditioning strategy with HLSC-EVs in an experimental...
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#1Luca Bertero (UNITO: University of Turin)H-Index: 14
#2Alessandro Gambella (UNITO: University of Turin)H-Index: 4
Last. Paola Cassoni (UNITO: University of Turin)H-Index: 56
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Aims null Novel prognostic markers are warranted for gastrointestinal stromal tumours. Caveolin-1 is a multifunctional protein that proved to be associated with outcome in multiple tumour types. Aim of this study was to investigate Caveolin-1 expression and prognostic efficacy in a series of gastrointestinal stromal tumours. null Methods null Caveolin-1 expression was assessed by immunohistochemistry in a retrospective series of 66 gastrointestinal stromal tumours representative of the different...
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Last. Mauro Papotti (UNITO: University of Turin)H-Index: 98
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: Pancreatic neuroendocrine tumors (PanNETs) are rare neoplasms that include even rarer variants that may pose different diagnostic problems, especially in fine needle aspiration cytology (FNAC). We describe the diagnostic clues of the amyloid-rich variant of PanNETs in endoscopic ultrasound (EUS)-guided fine needle aspiration cytology (EUS-FNAC). Three cases of PanNETs with an amyloid-rich stromal component were retrieved and retrospectively reviewed. For every case, the pancreatic lesion was i...
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#1Monica Sorbini (UNITO: University of Turin)
#2Gabriele Togliatto (UNITO: University of Turin)H-Index: 18
Last. Silvia DeaglioH-Index: 66
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Abstract Background Donor-derived cell-free DNA (dd-cfDNA) is considered a reliable marker of organ damage with potential applications in the follow-up of transplant recipients. Methods In this work we present an assay based on the donor-recipient HLA-mismatch at the HLA-DRB1 locus to monitor rejection by quantifying the percentage of dd-cfDNA using a droplet digital PCR technique. A panel of probes targeting the HLA-DRB1 locus and covering >85% genetic variability was validated and used to asse...
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#1Massimo Salvi (Polytechnic University of Turin)H-Index: 7
#2Alessandro Mogetta (Polytechnic University of Turin)H-Index: 1
Last. Filippo Molinari (Polytechnic University of Turin)H-Index: 35
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Abstract In kidney transplantations, pathologists evaluate the architecture of both glomeruli, interstitium and tubules to assess the nephron status. An accurate assessment of glomerulosclerosis and tubular atrophy is crucial for determining kidney acceptance, which is currently based on the pathologists’ histological evaluations on renal biopsies in addition to clinical data. In this work, we present an automated algorithm, called RENTAG (Robust EvaluatioN of Tubular Atrophy & Glomerulosclerosi...
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#1Loredana Pagano (UNITO: University of Turin)H-Index: 15
Last. Mauro Papotti (UNITO: University of Turin)H-Index: 98
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Several ultrasound (US) risk stratification systems (US-RSSs) have been proposed to stratify the risk of malignancy (ROM) of thyroid nodules. This risk might be overestimated due to selection bias and comparison with the cytological report alone. Our study aimed to compare ROM and diagnostic performance of three guidelines (ATA, AACE/ACE/AME, EUTIRADS) and evaluate the changes in unnecessary biopsy according to the nodule size cutoff for biopsy, using histology as gold standard. This retrospecti...
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#1Justin G. Aaron (Columbia University)H-Index: 4
#1Deepali Kumar (UHN: University Health Network)H-Index: 30
Last. Wendy Balliet (MUSC: Medical University of South Carolina)H-Index: 9
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3 CitationsSource
#1Massimo Salvi (Polytechnic University of Turin)H-Index: 7
#2M. BoscoH-Index: 2
Last. Filippo Molinari (Polytechnic University of Turin)H-Index: 35
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Abstract Background In digital pathology, the morphology and architecture of prostate glands have been routinely adopted by pathologists to evaluate the presence of cancer tissue. The manual annotations are operator-dependent, error-prone and time-consuming. The automated segmentation of prostate glands can be very challenging too due to large appearance variation and serious degeneration of these histological structures. Method A new image segmentation method, called RINGS (Rapid IdentificatioN...
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#1Massimo SalviH-Index: 7
#2M. BoscoH-Index: 2
Last. Filippo MolinariH-Index: 1
view all 7 authors...
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#1Francesca MalettaH-Index: 15
#2Enrico Costantino Falco (UNITO: University of Turin)H-Index: 1
Last. Mauro Papotti (UNITO: University of Turin)H-Index: 98
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In thyroid pathology, the great variety of types and the wide range of aggressiveness of thyroid cancers complicate both diagnosis and management. In 2016, a subset of noninvasive encapsulated follicular variant of papillary thyroid carcinoma was reclassified as noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) to reduce overtreatment of this low-risk tumor that follows a benign course after surgery. Starting from a paradigmatic clinical case, in this short review...
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