Malachi J. McKenna
University College Dublin
Vitamin D and neurologyInternal medicineEndocrinologySurgeryBone remodelingPediatricsProspective cohort studyYoung adultOsteoporosisBone mineralVitaminBisphosphonateOsteomalaciaPregnancyBone densityvitamin D deficiencyFemurPhysiologyCalciumDiabetes mellitusBone resorptionMedicineCohortGastroenterology
Publications 202
#4Clare D'Arcy (UCD: University College Dublin)H-Index: 4
#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
view all 8 authors...
Abstract null null Objectives null Clinical studies have reported an inverse relationship between calcium and vitamin D intake and hypertensive disorders of pregnancy (HDP). The aim of this study was to investigate if there was an association between calcium/vitamin D intake, and vitamin D (25OHD) status, and maternal blood pressure (BP), during pregnancy and at 5-year follow-up. null null null Study Design null This was an observational study of 415 women who participated in the ROLO (Randomise...
Denosumab was approved for the treatment of postmenopausal osteoporosis in 2010, based on the FREEDOM study, which indicated a benefit in terms of increased bone mineral density and reduced risk of...
#1Mark Kilbane (UCD: University College Dublin)H-Index: 13
#2Rachel K CrowleyH-Index: 17
Last. Patrick J TwomeyH-Index: 24
view all 5 authors...
Parathyroid hormone-related protein (PTHrP) can simulate most of the actions of parathyroid hormone (PTH) including increases in bone resorption and distal tubular calcium reabsorption and inhibition of proximal tubular phosphate transport.1 The low serum phosphate in parallel with low circulating PTH is consistent with PTHrP involvement in this case. Whether it can be causative for a serum calcium of 6.24 mmol/L however is a moot point. While the mechanism underlying the patient’s severe hyperc...
#1Nigel Glynn (Beaumont Hospital)H-Index: 7
#2David Halsall (University of Cambridge)H-Index: 36
Last. Amar Agha (Beaumont Hospital)H-Index: 24
view all 11 authors...
Abstract Objective: Growth hormone (GH) replacement alters the peripheral interconversion of thyroxine (T4) and triiodothyronine (T3). However, little is known about the clinical impact of these alterations. We aimed to compare changes observed in the serum T3:T4 ratio with known biological markers of thyroid hormone action derived from different peripheral tissues. Design: We prospectively studied twenty GH deficient men before and after GH replacement in a tertiary referral endocrine center. S...
#1E. C. O’Brien (UCD: University College Dublin)H-Index: 2
#2Aisling A. Geraghty (UCD: University College Dublin)H-Index: 10
Last. Fionnuala M. McAuliffe (UCD: University College Dublin)H-Index: 58
view all 5 authors...
BACKGROUND Pregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established. OBJECTIVE We aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum. DESIGN This is a prospective, longitudinal study of ...
#1Malachi J. McKenna (UCD: University College Dublin)H-Index: 29
#2Rachel K Crowley (UCD: University College Dublin)H-Index: 17
Last. Mark Kilbane (UCD: University College Dublin)H-Index: 13
view all 4 authors...
Excess fibroblast growth factor 23 (FGF23), excess PTH, and an increase in extracellular calcium cause hypophosphatemia by lowering the maximum renal phosphate reabsorption threshold (TmP/GFR). We recently reported two cases of X-linked hypophosphatemia (XLH) with severe tertiary hyperparathyroidism who had normalization of TmP/GFR upon being rendered hypoparathyroid following total parathyroidectomy, despite marked excess in both C-terminal FGF23 (cFGF23) and intact FGF23 (iFGF23). We explored ...
#10Chris Thompson (RCSI: Royal College of Surgeons in Ireland)H-Index: 12
Background Glucocorticoid therapy is the most common cause of iatrogenic osteoporosis. Less is known regarding the effect of glucocorticoids when used as replacement therapy on bone remodelling in patients with adrenal insufficiency. Enhanced intracellular conversion of inactive cortisone to active cortisol, by 11 beta-hydroxysteroid dehydrogenase type 1(11β-HSD1) and other enzymes leading to alterations in glucocorticoid metabolism, may contribute to a deleterious effect on bone health in this ...
#1William P. Martin (UCD: University College Dublin)H-Index: 8
#2Colm Tuohy (UCD: University College Dublin)H-Index: 1
Last. Neil G. Docherty (UCD: University College Dublin)H-Index: 30
view all 10 authors...
Identification of people with diabetes and chronic kidney disease at high-risk of early mortality is a priority to guide intensification of therapy. We aimed to investigate the complementary prognostic value of baseline urine albumin-to-creatinine ratio (uACR) and plasma soluble tumour necrosis factor receptor-1 (sTNFR1) with respect to early mortality and renal functional decline in a population with type 2 diabetes and advanced chronic kidney disease. We measured plasma sTNFR1 in people with t...
#1Aoife Garrahy (Beaumont Hospital)H-Index: 7
#2Iona Galloway (Beaumont Hospital)H-Index: 1
Last. Christopher J. Thompson (Beaumont Hospital)H-Index: 30
view all 13 authors...
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