Zhongxiang Zhao
Guangzhou University of Chinese Medicine
TriterpenoidPharmacokineticsAcid hydrolysisHigh-performance liquid chromatographyChemistryTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroOxidative stressOral administrationCisplatinFungusAnti-inflammatoryIlex rotundaTriterpenePositive controlChromatographyNitric oxideStereochemistryBiologyPharmacology
45Publications
13H-index
471Citations
Publications 45
Newest
Abstract null null Two undescribed shikimic acid derivatives named shikimerans B and C (1 and 2), one new natural compound shikimeran D (3), as well as five known compounds 4−8 were obtained from the EtOAc extract of the endophytic fungus Chaetomium sp. FZ-4. Their structures were determined by the NMR spectroscopy and HRESIMS examination, while the absolute configurations of compounds 1−3 were clarified based on the electronic circular dichroism (ECD) experiment. These new compounds enriched th...
Source
#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xiaocong Chen (Guangzhou University of Chinese Medicine)
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
view all 0 authors...
Abstract null null Furanaspermeroterpenes A (1) and B (2), with a unique 6/6/6/5/5 pentacyclic skeleton, and five new congeners aspermeroterpenes D–H (3–7) were co-isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Among them, compounds 1 and 2 with rare five-membered D/E coupling rings were the first example of DMOA-derived meroterpenoids. Moreover, compound 3 was the first reported 6/6/6/6/5 pentacyclic meroterpenoid featuring an unusual cis-fused A/B ring. In the bioassays,...
Source
#1Shiqin Jiang (Guangzhou University of Chinese Medicine)
#2Xiuting Shen (Guangzhou University of Chinese Medicine)
Last. Jing Jin (SYSU: Sun Yat-sen University)H-Index: 13
view all 8 authors...
Abstract Background : Croton crassifolius Geisel (CCG, also known as Ji-Gu-Xiang in Traditional Chinese Medicine), is traditionally prescribed for the therapy of rheumatic arthritis and gastrointestinal ulcer. However, the effect of CCG on ulcerative colitis (UC) has not been investigated. Purpose : To explore the therapeutic potential and underlying mechanism of CCG extract against UC by colonic and serum metabolomics. Methods : In order to standardize the CCG extract, UPLC-QTOF-MS was used for...
Source
#1Qingfeng RuanH-Index: 6
#2Wencong PanH-Index: 1
Last. Zhongxiang ZhaoH-Index: 13
view all 9 authors...
Abstract Nine previously undescribed butyrolactone and sesquiterpene derivatives, named cyclopentanone A (1), subamolides F and G (2 and 3), secosubamolide F (4), rupestonic acids J − L (5–7), linderaguaianols A and B (8 and 9), together with six known ones 10–15 were isolated from the roots of Lindera glauca. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and Mo2(AcO)4-induced circular dichroism. Comp...
Source
#1Feifei Nong (Guangzhou University of Chinese Medicine)H-Index: 3
#2Shuang Luo (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Lian Zhou (Guangzhou University of Chinese Medicine)H-Index: 11
view all 7 authors...
Dahuang-Mudan decoction (DMD) is a formula that has been widely used as a complementary treatment for inflammatory bowel disease (IBD). However, the mechanism of action of DMD in IBD has not been clearly elucidated. Therefore, we developed a metabolomics-based method to evaluate the effects and potential mechanisms of DMD in a 2,4,6-trinitobenzene sulfonic acid (TNBS)-induced colitis model. The ultra-high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/QTOF-MS...
Source
#1Lin Cao (SYSU: Sun Yat-sen University)H-Index: 3
#2Weipeng Hong (SYSU: Sun Yat-sen University)H-Index: 3
Last. Jing Jin (SYSU: Sun Yat-sen University)H-Index: 12
view all 8 authors...
Lung cancer is the leading cause of cancer-related mortality and causes more than a million deaths per year. Gefitinib is the first-line agent of advanced lung cancer, however, resistance to gefitinib becomes a major problem in clinical application. Transketolase (TKT) is a key enzyme functioning between the oxidative arm and the non-oxidative arm of the pentose phosphate pathway. In this study, we firstly found that the expression of TKT was remarkably up-regulated in NSCLC cells, while the kno...
Source
#1Min Zhao (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Hui Cui (Guangzhou University of Chinese Medicine)
view all 5 authors...
Meroterpenoids are partially derived from the terpenoids, distributing widely in the plants, animals and fungi. The complex structures and diverse bioactivities of meroterpenoids have attracted more attention for chemists and pharmacologists. Since the first review summarized by Geris in 2009, there are absent of systematic reviews reported about meroterpenoids from the higher and lower fungi up to now. In the past decades, myriads of meroterpenoids were discovered, and it is necessary to summar...
2 CitationsSource
#1Aizhi Wu (Guangzhou University of Chinese Medicine)H-Index: 1
#1Ai-Zhi Wu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Chen-Chen Zhu (Guangzhou University of Chinese Medicine)H-Index: 11
view all 9 authors...
Abstract Callicarpa kwangtungensis, as a characteristic traditional herb in China, has been widely used as indigenous medicine for thousands of years in the treatment of gynecological inflammatory disease in China. Phenylethanoid glycosides (PhGs), as natural polyphenols, are especially abundant in this herb and can be regarded as the representative active ingredients in C. kwangtungensis. This study was performed to investigate the anti-inflammatory pharmacodynamic basis of six PhGs (acteoside,...
2 CitationsSource
#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yanwen Li (SYSU: Sun Yat-sen University)H-Index: 1
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
view all 8 authors...
Abstract Furanasperterpenes A (1) and B (2) with a novel 6/6/6/6/5 pentacyclic skeleton and a new 11-acetoxy-terretonin E (3), were isolated from the marine-derived Aspergillus terreus GZU-31-1. Their structures were elucidated based on spectroscopic methods, and the absolute configurations were determined by X-ray diffraction and electronic circular dichroism (ECD) calculations. A possible biogenetic pathway was proposed. These compounds were evaluated for their lipid-lowering effects in 3T3-L1...
4 CitationsSource
#1Bao Yang (Guangzhou University of Chinese Medicine)H-Index: 7
#2Shenxin Xuan (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
view all 9 authors...
ETHNOPHARMACOLOGICAL RELEVANCE: Ilicis Rotundae Cortex (IRC), a Chinese crude drug, has been widely utilized in Guangdong and Guangxi provinces of China to treat or prevent cardiovascular diseases. AIM OF STUDY: This investigation aims to study the lipid-lowering effect of IRC, as well as the regulating effect on the endogenous metabolites in hyperlipidemia rats. MATERIALS AND METHODS: High-fat diet induced hyperlipidemia rats were administrated with different doses of IRC extract (0.5, 1.0 and ...
4 CitationsSource