Yuqian Tang
Guangzhou University of Chinese Medicine
BioassayDocking (molecular)Circular dichroismMolecular biologyEnzymeChemistrySkeleton (computer programming)Side chainTerpenoidSesquiterpeneMoietyAspergillus terreusSecondary metaboliteIC50Diphenyl etherCyclopentaneNatural productFungusAnti-inflammatoryBerberineCyclopentanoneRing (chemistry)Nitric oxide biosynthesisRAW 264.7 CellsLindera glaucaQuantum chemicalStructural diversityPositive controlIc50 valuesClassification methodsMolecular targetsMoleculeNitric oxideDouble bondProtein expressionStereochemistryEvolutionary biology
7Publications
4H-index
30Citations
Publications 7
Newest
#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xiaocong Chen (Guangzhou University of Chinese Medicine)
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
view all 9 authors...
Abstract null null Furanaspermeroterpenes A (1) and B (2), with a unique 6/6/6/5/5 pentacyclic skeleton, and five new congeners aspermeroterpenes D–H (3–7) were co-isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Among them, compounds 1 and 2 with rare five-membered D/E coupling rings were the first example of DMOA-derived meroterpenoids. Moreover, compound 3 was the first reported 6/6/6/6/5 pentacyclic meroterpenoid featuring an unusual cis-fused A/B ring. In the bioassays,...
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#1Qingfeng RuanH-Index: 6
#2Wencong PanH-Index: 1
Last. Zhongxiang ZhaoH-Index: 13
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Abstract Nine previously undescribed butyrolactone and sesquiterpene derivatives, named cyclopentanone A (1), subamolides F and G (2 and 3), secosubamolide F (4), rupestonic acids J − L (5–7), linderaguaianols A and B (8 and 9), together with six known ones 10–15 were isolated from the roots of Lindera glauca. Their structures, including their absolute configurations were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and Mo2(AcO)4-induced circular dichroism. Comp...
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#1Min Zhao (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Hui Cui (Guangzhou University of Chinese Medicine)
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Meroterpenoids are partially derived from the terpenoids, distributing widely in the plants, animals and fungi. The complex structures and diverse bioactivities of meroterpenoids have attracted more attention for chemists and pharmacologists. Since the first review summarized by Geris in 2009, there are absent of systematic reviews reported about meroterpenoids from the higher and lower fungi up to now. In the past decades, myriads of meroterpenoids were discovered, and it is necessary to summar...
5 CitationsSource
#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yanwen Li (SYSU: Sun Yat-sen University)H-Index: 1
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Furanasperterpenes A (1) and B (2) with a novel 6/6/6/6/5 pentacyclic skeleton and a new 11-acetoxy-terretonin E (3), were isolated from the marine-derived Aspergillus terreus GZU-31-1. Their structures were elucidated based on spectroscopic methods, and the absolute configurations were determined by X-ray diffraction and electronic circular dichroism (ECD) calculations. A possible biogenetic pathway was proposed. These compounds were evaluated for their lipid-lowering effects in 3T3-L1...
6 CitationsSource
#1Min Zhao (Guangzhou University of Chinese Medicine)H-Index: 4
#2Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Abstract Two new compounds, named penisclerotiorin A (1) and diaporthein C (8), and a new natural product, penidepsidone A (4), together with five known compounds (2, 3, 5–7) were isolated from the fungus Penicillium sclerotiorum GZU-XW03–2. Their structures were assigned using spectroscopic methods, quantum chemical calculations, and single-crystal X-ray diffraction analysis. Penisclerotiorin A (1) that belongs to the highly oxidized diphenyl ether is rare found in natural sources, and it was t...
4 CitationsSource
#1Yuqian Tang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yena Liu (SYSU: Sun Yat-sen University)H-Index: 8
Last. Hui Cui (Guangzhou University of Chinese Medicine)H-Index: 6
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Aspermeroterpene A (1) with an unprecedented and highly congested 5/3/6/6/6/5 hexacyclic skeleton, together with two precursors aspermeroterpenes B (2) and C (3), were isolated from the marine-derived fungus Aspergillus terreus GZU-31-1. Their structures were elucidated by quantum chemical calculations, X-ray diffraction, and spectroscopic methods. The biogenetic pathway for 1–3 is proposed. Aspermeroterpenes A–C (1–3) showed significant inhibitory activities against lipopolysaccharide (LPS)-ind...
13 CitationsSource
#1Qingfeng Ruan (Guangzhou University of Chinese Medicine)H-Index: 6
#2Shiqin Jiang (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Zhongxiang Zhao (Guangzhou University of Chinese Medicine)H-Index: 13
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Pseudoguaianelactones A (1) and B (2), two novel sesquiterpene lactones with an unprecedented [5, 7, 7] ring system featuring a α-methylene-γ-lactone moiety, together with new pseudoguaianelactone C (3), were isolated from the roots of Lindera glauca. Pseudoguaianelactones A–C (1–3) inhibited NO production with IC50 values ranging from 1.38 to 4.00 μM. Moreover, all compounds suppressed significantly the production of proinflammatory mediator (TNF-α, IL-6, IL-1β and PGE2) and the enzyme expressi...
2 CitationsSource