Yan Chen
Guangzhou University of Chinese Medicine
KinaseChemistryNeuroprotectionTLR4Western blotNitric oxide synthaseLipopolysaccharideMonocyteNeuroinflammationCell biology
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#1Zhao Qu (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yan Chen (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Ying-Jie Hu (Guangzhou University of Chinese Medicine)H-Index: 6
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OBJECTIVES: Neuroprotective potential of 7-methoxyflavanone (7MF) and its underlying mechanism was investigated. METHODS: Inhibitory effects of 7MF on microglial activation and neuroinflammation were evaluated by employment of lipopolysaccharide (LPS)-induced BV2 microglial cells. Changes in expression of genes and proteins of interest were investigated by RT-qPCR analysis and Western blot analysis. Inhibitory effects of 7MF on microglial overactivation were verified in LPS-treated C57BL/6J mice...
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