Ahmed Shaukat
Aalto University
PolysaccharideDNA origamiBiocompatible materialNanomaterialsSerum albuminNanotechnologyNanocarriersChemistryNanostructureMaterials scienceConjugateBioconjugationNeuroprotectionSelf-assemblyOxidative stressMoietySinglet oxygenHeparinAntioxidantPeptideJanusBlood transfusionPiceinPhthalocyanineMenadionePhotodynamic therapyPhotosensitizerMitochondrionAnticoagulant AgentEnzymatic digestionMoleculeNanoscopic scaleReactive oxygen speciesBiomoleculeCarbon nanotubeDNAOxidative phosphorylationPhotocatalysisPhotochemistryPharmacology
Publications 5
#1Asma Rahali (Carthage University)
#1Asma Rahali (Carthage University)H-Index: 1
Last. Eduardo Anaya-Plaza (Aalto University)H-Index: 8
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Design and synthesis of novel photosensitizer architectures is a key step toward new multifunctional molecular materials. Photoactive Janus-type molecules provide interesting building blocks for such systems by presenting two well-defined chemical functionalities that can be utilized orthogonally. Herein a multifunctional phthalocyanine is reported, bearing a bulky and positively charged moiety that hinders their aggregation while providing the ability to adhere on DNA origami nanostructures via...
#1Eduardo Anaya-Plaza (Aalto University)H-Index: 8
#2Ahmed Shaukat (Aalto University)H-Index: 3
Last. Mauri A. Kostiainen (Aalto University)H-Index: 36
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The strategy of combining biomolecules and synthetic components to develop biohybrids is becoming increasingly popular for preparing highly customized and biocompatible functional materials. Carbon nanotubes (CNTs) benefit from bioconjugation, allowing their excellent properties to be applied to biomedical applications. This study reviews the state-of-the-art research in biomolecule-CNT conjugates and discusses strategies for their self-assembly into hierarchical structures. The review focuses o...
3 CitationsSource
#1Ahmed Shaukat (Aalto University)H-Index: 3
#2Eduardo Anaya-Plaza (Aalto University)H-Index: 8
Last. Mauri A. Kostiainen (Aalto University)H-Index: 36
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In this communication, electrostatically assembled phthalocyanine (Pc)-DNA origami (DO) complexes are formed and their optical properties are demonstrated. The formation of the complex prevents the Pc aggregation, thus yielding an enhanced optical response and photooxidative resilience towards aggregation in biologically-related media. Simultaneously, the Pc protects the DO against enzymatic digestion. Both features solve previous drawbacks associated with phthalocyanine photosensitizers and DNA...
5 CitationsSource
#1Kavindra Kumar Kesari (Aalto University)H-Index: 23
#1Kavindra Kumar Kesari (Aalto University)H-Index: 2
Last. Janne Ruokolainen (Aalto University)H-Index: 67
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Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. Historically, willow (salix sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Among these, picein isolated from hot water extract of willow bark, has been found to act as a natural secondary metabolite antioxidant. The aim of this study was to investigate the unreveale...
6 CitationsSource
#1Qing Liu (Aalto University)H-Index: 9
#2Salla Välimäki (Aalto University)H-Index: 5
Last. Mauri A. Kostiainen (Aalto University)H-Index: 36
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Heparin is a polysaccharide-based anticoagulant agent, which is widely used in surgery and blood transfusion. However, overdosage of heparin may cause severe side effects such as bleeding and low blood platelet count. Currently, there is only one clinically licensed antidote for heparin: protamine sulfate, which is known to provoke adverse effects. In this work, we present a stable and biocompatible alternative for protamine sulfate that is based on serum albumin, which is conjugated with a vari...
4 CitationsSource