Jing Zhang
Jilin University
P70-S6 Kinase 1GeneInternal medicineEndocrinologyWnt signaling pathwayUnfolded protein responseGenomemicroRNAMolecular biologyEndoplasmic reticulumReceptorTumor necrosis factor alphaPhotosynthesisChemistryApoptosisSuperoxide dismutaseSOD2Oxidative stressInflammationFatty acid synthesisZearalenonePteridium aquilinumFatty acid synthaseReactive oxygen speciesCancer researchViability assayGlutathioneGeneticsBiochemistryBotanySignal transductionAgronomyHsp70Sterol regulatory element-binding proteinBiologyMicrobiologyCell biology
23Publications
5H-index
95Citations
Publications 23
Newest
#1Ruihua LiH-Index: 4
#2Hengtong FangH-Index: 4
Last. Jing ZhangH-Index: 5
view all 10 authors...
Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. The purpose of this study is to investigate whether CUR can reduce the damage of bovine mammary epithelial cells (MAC-T) induced by LPS and its underlying molecular mechanism. ...
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#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Yue Tian (JLU: Jilin University)
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Zearalenone (ZEA) is a mycotoxin of the Fusarium genus that can cause endoplasmic reticulum (ER) stress and Apoptosis in bovine mammary epithelial cells (MAC-T). Polydatin (PD), a glycoside purified from Polygonum cuspidatum, has antioxidant properties. This study aimed to explore whether PD can alleviate ZEA-induced damage on bovine mammary epithelial cells (MAC-T). We found that incasing the concentration of ZEA (0, 7.5, 15, 30, 60, 90, 120, and 240 μM) gradually decreased the cell viability. ...
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#1Jing Zhang (JLU: Jilin University)H-Index: 5
#2JunMei Wang (Sichuan Agricultural University)
Last. Yongcheng Jin (JLU: Jilin University)H-Index: 8
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Abstract More and more studies have showed that tricothecene mycotoxin, deoxynivalenol (DON) caused cytotoxicity in mammary alveolar cells-large T antigen cells (MAC-T). Therefore, research on reducing the cytotoxicity of DON has gradually attracted attention. In this study, we aim to explore the potential of pterostilbene (PTE) to protect MAC-T cells from DON-induced oxidative stress and inflammatory response. MAC-T cells were treated with 0.25 μg/mL DON or 2.0504 μg/mL PTE or 0.25 μg/mL DON an...
1 CitationsSource
#1Ruihua LiH-Index: 4
#2Jing ZhangH-Index: 5
Last. Hao YuH-Index: 8
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Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. Curcumin (CUR), a well-known cancer inhibitor, significantly inhibits the viability of breast cancer cells. Through transcriptomic analysis and flow cytometry experiments, it was found that after 48 hours of treatment of breast cancer cells at its half maximal inhibitory concentration (IC50), curcumin suppressed the viability of cancer cells via induction of ferroptotic death. Use of the ...
3 CitationsSource
#1Xian-Dong Liao (JLU: Jilin University)H-Index: 1
#2Changhai Zhou (JLU: Jilin University)H-Index: 5
Last. Shengli Li (CAU: China Agricultural University)H-Index: 11
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OBJECTIVE: Caseins and fatty acids of milk are synthesized and secreted by the epithelial cells of the mammary gland. All-trans retinoic acid (ATRA), an active metabolite of vitamin A, has been shown to promote mammary development. This study was conducted to determine the effect of ATRA on casein synthesis and fatty acid composition in MAC-T cells. METHODS: MAC-T cells were allowed to differentiate for 4 d, treated with ATRA (0, 1.0, 1.5, and 2.0 muM), and incubated for 3 d. We analyzed the fat...
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#1Rui Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 11 authors...
Grape pomace (GP) is an abundant by-product from wine production and is rich in phenolic compounds, unsaturated fatty acids, dietary fibre and beneficial bacteria. In this study, weaned piglets were fed a basic diet supplemented with 5% GP for 4 weeks. Compared with those in the control (CON) group, it was found that the proportion of Lactobacillus delbrueckii, Olsenella umbonata and Selenomonas bovis in the caecum and the villus height and villus height/crypt depth ratio (VCR) of the jejunum we...
1 CitationsSource
#1Wanqi Zhong (JLU: Jilin University)H-Index: 1
#2Jinglin Shen (JLU: Jilin University)H-Index: 4
Last. Yongcheng Jin (JLU: Jilin University)H-Index: 8
view all 7 authors...
Camellia (Camellia oleifera Abel.) seed oil is a commonly used edible oil of China. In ancient Chinese literature, it is mentioned to be helpful for postpartum repair and lactation in women. Research on camellia seed oil (CO) as a feed additive for dairy cattle is less. We investigated the effect of CO on the expression of milk fat and protein syntheses-related genes in differentiated bovine mammary epithelial cells (MAC-T) using soybean oil (SO) as the control. The results showed that CO increa...
3 CitationsSource
#1Jing ZhangH-Index: 5
#2Xin WangH-Index: 4
Last. Hao YuH-Index: 8
view all 11 authors...
1 CitationsSource
#1Xin Wang (JLU: Jilin University)H-Index: 4
#2Hao Yu (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 11 authors...
Abstract Mounting evidence has shown that zearalenone (ZEA) can have toxic effects on the intestinal epithelial cells (IECs) of mammals and humans, but the mechanism of ZEA-induced toxicity on IECs is unclear. The aim of this study was to reveal the mechanism of action of ZEA on intestinal epithelial cells via RNA-seq technology. We measured the effects of ZEA on the viability and lactate dehydrogenase (LDH) activity of the pig intestinal epithelial cell line J2 (IPEC-J2). The results showed ZEA...
4 CitationsSource
#1Yurong Fu (JLU: Jilin University)H-Index: 4
#2Yongcheng Jin (JLU: Jilin University)H-Index: 8
Last. Jing Zhang (JLU: Jilin University)H-Index: 5
view all 14 authors...
ABSTRACT Zearalenone (ZEA) is a common mycotoxin produced by fungi within the genus Fusarium. However, few studies have examined the direct effects of the toxin on the mammary glands. In the present study, the effects of ZEA treatment on bovine mammary epithelial cells (MAC-T) from dairy cows were investigated. The cells were treated with different concentrations of ZEA to evaluate the effect of the toxin on cell viability, intracellular reactive oxygen species (ROS) concentrations, mitochondria...
5 CitationsSource