Tingting Liu
Shenyang Pharmaceutical University
Therapeutic effectFourier transform ion cyclotron resonanceCarbohydrate metabolismHigh-performance liquid chromatographyChemistryMetabolomicsHepatitisOxidative stressPaeoniflorinArthritisMetaboliteRheumatoid arthritisFatty liverAmlodipineIcariinLiver functionHepatic fibrosisChromatographyPK/PD modelsPharmacology
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Publications 4
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
view all 6 authors...
Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, 1H NMR and MS-based metabolomics analysis along...
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#1Yumeng Zhang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
view all 6 authors...
Abstract Yinchen Wuling Powder (YCWLP) is a classic Chinese medicine prescription with a long history and has been commonly used for treating jaundice hepatitis, liver fibrosis, hyperlipidemia and early diabetes in clinical applications. However, the chemical composition of YCWLP is still unclear. In order to obtain the chemical profile of YCWLP, a systematic ultra-performance liquid chromatography coupled with fourier transform ion cyclotron resonance mass spectrometry (UPLC-FT-ICR-MS) method w...
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#1Tingting Liu (SPU: Shenyang Pharmaceutical University)
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Miao Wang (SPU: Shenyang Pharmaceutical University)H-Index: 8
view all 7 authors...
Clinically, Wangbi Capsule (WBC) is widely used in the treatment of Rheumatoid arthritis (RA) because of its remarkable therapeutic effect. To reveal the mechanism, a pharmacokinetic-pharmacodynamic (PK-PD) model was developed for the first time to assess the relationship between time-concentration (dose)-effect. Freund's Complete Adjuvant (FCA) was used to induce the Adjuvant-Induced Arthritis (AIA) model. Multi-index were used to evaluate the therapeutic effect and a S-Imax PK-PD model was est...
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#1Jingwei Li (SPU: Shenyang Pharmaceutical University)
#2Min Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 8
Last. Chunjie Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 6
view all 6 authors...
Duzhong Jiangya Tablet (DJT) composed of Eucommia ulmoides Oliv. and several other traditional Chinese medicines is a Chinese herbal compound, which is clinically used to treat hypertension. The aim of this study was to evaluate the antihypertensive effect of DJT and amlodipine besylate (AB) on the synergistic treatment of spontaneously hypertensive rats (SHRs), and to explore its antihypertensive mechanism. The synergistic therapeutic effect of DJT in combination with AB on SHR was studied usin...
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