Abdelkader Naouri
CytotoxicityAlkylationChemistryTwo-dimensional nuclear magnetic resonance spectroscopyCombinatorial chemistryMoiety1,3-Dipolar cycloadditionTriazoleBenzimidazoleBenzyl groupCycloadditionChalconeAzideIsoxazoleCoupling reactionRegioselectivityClick chemistry
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#1Abdelkader NaouriH-Index: 2
#2Amar DjemouiH-Index: 2
Last. Artur M. S. Silva (University of Aveiro)H-Index: 46
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Abstract A new series of diverse 1,2,3-triazole-acridinedione/xanthenedione and 1,2-isoxazole-acridinedione/xanthenedione heterocyclic hybrids have been synthesized via 1,3-dipolar coupling reaction of N/O-substituted-acridinedione-alkyne or O-substituted-xanthenedione-alkyne substrates with various aromatic azides or oximes. In all cases, the cycloaddition is totally regioselective. The chemical structures of the synthesized compounds are determined using 2D NMR and are further confirmed by sin...
3 CitationsSource
#1Amar DjemouiH-Index: 2
#2Abdelkader NaouriH-Index: 2
Last. Artur M. S. Silva (University of Aveiro)H-Index: 46
view all 15 authors...
Abstract Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized via click chemistry, between different azide derivatives and substituted benzimidazole terminal alkynes bearing a chalcone moiety. The starting alkynes are prepared via base-catalysed nitrogen alkylation of pre-synthetized benzimidazole-chalcone substrates. All the intermediates as well as the final products are fully characterized by 1D and 2D NMR and mass spectrometry techniques. HMBC correlations p...
3 CitationsSource
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