Andres Santos
Texas Tech University Health Sciences Center
TransgeneMatrix metalloproteinaseChagas diseaseHaCaTPhenotypeFunction (biology)Viral replicationCytoskeletonSUMO enzymesCellular differentiationCellSingle-nucleotide polymorphismMolecular biologyMultiplicationVirologyPhagocytosisProinflammatory cytokineNanotechnologySUMO proteinHEK 293 cellsChemistryUltrabithoraxVirusCD163Humanized mouseInterferonMammary tumorInflammationKeratinocyteTropical diseaseInfluenza A virusTrypanosoma cruziAlveolar macrophageImmunofluorescenceTrypanosoma bruceiAngiogenesisTarget proteinLeishmania majorSUMO2Drosophila ProteinPopulationLung alveolusCell cycleCellular localizationMetastatic cellTumorigenic cellCluster of differentiationCancer researchPlasma protein bindingTransfectionFlow cytometryMyristoylationCell cultureBiologyCell biologyAmastigote
11Publications
5H-index
118Citations
Publications 9
Newest
#1Jesse Vance (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 2
#2Andres Santos (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 5
Last. Jorge Cervantes (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 8
view all 5 authors...
Purpose Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM.
9 CitationsSource
#1Ramesh T. Gunaratna (Princeton University)H-Index: 1
#2Andres Santos (Texas A&M Health Science Center)H-Index: 5
Last. Robin Fuchs-Young (A&M: Texas A&M University)H-Index: 19
view all 8 authors...
Female breast cancer (BrCa) is the most common noncutaneous cancer among women in the United States. Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa. However, the molecular mechanisms by which these variants affect mammary tumorigenesis remain unresolved. To investigate the effects of this polymorphism on susceptibility to mammary can...
7 CitationsSource
#1Hao-Ching HsiaoH-Index: 6
#2Andres Santos (A&M: Texas A&M University)H-Index: 5
Last. Sarah E. BondosH-Index: 17
view all 6 authors...
Tumorigenic cell behaviors can be suppressed or enhanced by their physicochemical environment. As a first step toward developing materials that allow tumorigenic behaviors to be observed and manipulated, we cultured related MCF10 breast cell lines on fibers composed of the Drosophila protein Ultrabithorax (Ubx). These cell lines, originally derived from fibrocystic breast tissue, represent a continuum of tumorigenic behavior. Immortal but nontumorigenic MCF10A cells, as well as semitumorigenic M...
3 CitationsSource
#1Linda J. Herrera (UTEP: University of Texas at El Paso)H-Index: 3
#2Stephen Brand (Dund.: University of Dundee)H-Index: 17
Last. Rosa A. Maldonado (UTEP: University of Texas at El Paso)H-Index: 14
view all 13 authors...
Background Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected tropical disease has become a global health concern. The two clinically available drugs for the chemotherapy of Chagas disease have rather high toxicity and limited efficacy in the chronic phase of the disease, and may induce parasite resistance. The development of new anti-T. cruzi agents is therefore imperative. The enzyme N-m...
16 CitationsSource
#1Andres Santos (UTEP: University of Texas at El Paso)H-Index: 5
#2Sangita Pal (UTEP: University of Texas at El Paso)H-Index: 10
Last. Germán Rosas-Acosta (UTEP: University of Texas at El Paso)H-Index: 15
view all 7 authors...
ABSTRACT Our pioneering studies on the interplay between the small ubiquitin-like modifier (SUMO) and influenza A virus identified the nonstructural protein NS1 as the first known SUMO target of influenza virus and one of the most abundantly SUMOylated influenza virus proteins. Here, we further characterize the role of SUMOylation for the A/Puerto Rico/8/1934 (PR8) NS1 protein, demonstrating that NS1 is SUMOylated not only by SUMO1 but also by SUMO2/3 and mapping the main SUMOylation sites in NS...
30 CitationsSource
#1Andres SantosH-Index: 5
#2Jason ChacónH-Index: 2
Last. Germán Rosas-AcostaH-Index: 15
view all 3 authors...
2 CitationsSource
#1Phillip R. Heaton (Texas A&M Health Science Center)H-Index: 4
#2Andres Santos (Texas A&M Health Science Center)H-Index: 5
Last. Van G. Wilson (Texas A&M Health Science Center)H-Index: 25
view all 4 authors...
Sumoylation is a highly dynamic process that plays a role in a multitude of processes ranging from cell cycle progression to mRNA processing and cancer. A previous study from our lab demonstrated that SUMO plays an important role in keratinocyte differentiation. Here we present a new method of tracking the sumoylation state of proteins by creating a stably transfected HaCaT keratinocyte cell line expressing an inducible SNAP-SUMO3 protein. The SNAP-tag allows covalent fluorescent labeling that i...
2 CitationsSource
#1Sangita Pal (UTEP: University of Texas at El Paso)H-Index: 10
#2Andres Santos (UTEP: University of Texas at El Paso)H-Index: 5
Last. Germán Rosas-Acosta (UTEP: University of Texas at El Paso)H-Index: 15
view all 5 authors...
Abstract SUMOylation, the post-translational conjugation of the Small Ubiquitin-like MOdifier (SUMO) to a target protein, regulates a wide array of cellular processes and plays important roles for numerous viruses during infection. However, the relevance of the cellular SUMOylation system for influenza virus infection remains mostly unexplored. We previously reported that the non-structural protein of influenza A virus NS1 is a bona fide SUMO target. Here we determine that at least four addition...
49 CitationsSource
Close Researchers
Germán Rosas-Acosta
H-index : 15
University of Texas at El Paso
Sangita Pal
H-index : 10
Harvard University
Robin Fuchs-Young
H-index : 19
Texas A&M Health Science Center
Jason Chacón
H-index : 2
University of Texas at El Paso
Adalid Fj
Martí M
Justin R. Harrison
H-index : 10
University of Dundee
B. Ortega
Hospital Universitario La Paz
Madison Spier
H-index : 1
Texas A&M Health Science Center
Carolina Lema
H-index : 11
University of Texas at El Paso
David W. Howell
H-index : 4
Texas A&M University
Jan Patterson
H-index : 6
Texas A&M University
Linda J. Herrera
H-index : 3
University of Texas at El Paso
Igor C. Almeida
H-index : 62
University of Texas at El Paso
Lilian L. Nohara
H-index : 8
University of Texas at El Paso
Laura R. Sadofsky
H-index : 12
Hull York Medical School
Sarah E. Bondos
H-index : 17
Texas A&M University
J.I. Chacon Lopez-Muñiz
Rosa A. Maldonado
H-index : 4
University of Texas at El Paso
Alyn H. Morice
H-index : 2
Hull York Medical School
R. Álvarez-Sala
Ruiz Ja
Gomez Mendieta Ma
Herruzo R
Pantilde
Martinez-Verdasco A
Castillo F
HN flu
Quintana M
Garcia de Miguel Mj
Martinez Virto A
Martin Vega A
Sanchez Pastor M
Arnalich F
Alcolea S
Martin-Quiros A
C. Prados
A. Santiago
Ramesh T. Gunaratna
H-index : 1
Princeton University
Antonio Irigoyen
H-index : 3
Jesse Vance
H-index : 2
Texas Tech University Health Sciences Center at El Paso
Juan David Cardenas
Ian H. Gilbert
H-index : 55
University of Dundee
K. Martinez Barroso
R. Alvarez Cabellos
M. Borregon Rivilla
C. Esteban Esteban
J. Andrade Santiago
Linjie Luo
H-index : 2
Texas A&M Health Science Center
E. Muñoz Platón
E. Martinez Moreno
H-index : 1
David Barros
H-index : 1
Hospital Universitario La Paz
J. Fernández-Bujarrabal
H-index : 1
Hospital Universitario La Paz
Karla Prieto
H-index : 1
University of Texas at El Paso
Neil R. Norcross
H-index : 9
University of Dundee
Juan M. Rosas
H-index : 2
University of Texas at El Paso
Chandandeep Nagi
H-index : 9
Baylor College of Medicine
Joshua Ortiz-Guzman
H-index : 1
University of Texas at El Paso
Stephen Thompson
H-index : 13
University of Dundee
Claudio J. Conti
H-index : 63
Charles III University of Madrid
I. Burgueño Lorenzo
B. Trujillo Alba
Jorge Cervantes
H-index : 8
Texas Tech University Health Sciences Center at El Paso
Romero Mp
Figueiras Jc
Katherine Meraz
H-index : 1
University of Texas at El Paso
Jeanette Gonzalez
H-index : 1
University of Texas at El Paso
Stephen Brand
H-index : 17
University of Dundee
Victoria Smith
H-index : 8
University of Dundee
Van G. Wilson
H-index : 25
Texas A&M Health Science Center
Phillip R. Heaton
H-index : 4
Texas A&M University
Hao-Ching Hsiao
H-index : 6
Texas A&M University
Isabel Lambertz
H-index : 7
Texas A&M Health Science Center
Armando Varela-Ramirez
H-index : 21
University of Texas at El Paso