Sanam J. Lalani
University of California, San Francisco
Verbal memoryInternal medicineDevelopmental psychologyDefault mode networkMagnetic resonance imagingSynaptic vesicleDiffusion MRIPsychologyNeuroscienceCognitionExocytosisElectrophysiologyVAMP2NeurotransmissionDysfunctional familySuperior frontal gyrusHippocampal sclerosisCorpus callosumEpilepsyAnterior cingulate cortexPotassium channel blockerAutism spectrum disorderFornixConnectomicsGABAergicDementiaUncinate fasciculusAnterior temporal lobectomyArcuate fasciculusBody mass indexOverweightInferior longitudinal fasciculusTraumatic brain injuryTemporal lobeHippocampusWhite matterPrecuneusPopulationSynaptic vesicle recyclingCognitive declineVolumetric magnetic resonance imagingVerbal learningSocial functionPoison controlMemory impairmentAuditory attentionPediatric brainConnectomeVolume (compression)AudiologyMedicineCohortBiologyEpisodic memoryFractional anisotropy
8Publications
3H-index
23Citations
Publications 8
Newest
#1Sanam J. Lalani (UCSF: University of California, San Francisco)H-Index: 3
#2Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 39
view all 11 authors...
OBJECTIVE Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In...
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#1Roxanne Simmons (UCSF: University of California, San Francisco)H-Index: 1
Clinical and genetic features of five unrelated patients with de novo pathogenic variants in the synaptic vesicle associated membrane protein VAMP2 reveal common features of global developmental delay, autistic tendencies, behavioral disturbances, and a higher propensity to develop epilepsy. For one patient, a cognitively impaired adolescent with a de novo stop-gain VAMP2 mutation, we tested a potential treatment strategy, enhancing neurotransmission by prolonging action potentials with the amin...
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#1Hannah M. Lindsey (BYU: Brigham Young University)H-Index: 7
#2Sanam J. Lalani (BYU: Brigham Young University)H-Index: 3
Last. Harvey S. Levin (BCM: Baylor College of Medicine)H-Index: 89
view all 12 authors...
Mediation analysis was used to investigate the role of white matter integrity in the relationship between injury severity and verbal memory performance in participants with chronic pediatric traumatic brain injury (TBI). DTI tractography was used to measure fractional anisotropy (FA) within the corpus callosum, fornix, cingulum bundles, perforant pathways, and uncinate fasciculi. Injury severity was indexed using Glasgow Coma Scale (GCS) scores obtained at the time of the injury. Verbal memory w...
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#1Akshara R. Balachandra (MUSC: Medical University of South Carolina)H-Index: 7
#2Erik KaestnerH-Index: 12
Last. Carrie R. McDonaldH-Index: 39
view all 9 authors...
Objective To determine the predictive power of white matter neuronal networks (i.e., structural connectomes [SCs]) in discriminating memory-impaired patients with temporal lobe epilepsy (TLE) from those with normal memory. Methods T1- and diffusion MRI (dMRI), clinical variables, and neuropsychological measures of verbal memory were available for 81 patients with TLE. Prediction of memory impairment was performed with a tree-based classifier (XGBoost) for 4 models: (1) a clinical model including...
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#1Erik Kaestner (UCSD: University of California, San Diego)H-Index: 12
#2Akshara R. Balachandra (UCSD: University of California, San Diego)H-Index: 7
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 39
view all 11 authors...
ABSTRACT Objective The distributed white matter network underlying language leads to difficulties in extracting clinically meaningful summaries of neural alterations leading to language impairment. Here we determine the predictive ability of the structural connectome (SC), compared with global measures of white matter tract microstructure and clinical data, to discriminate language impaired patients with temporal lobe epilepsy (TLE) from TLE patients without language impairment. Methods T1- and ...
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#1Anny Reyes (UCSD: University of California, San Diego)H-Index: 10
#2Sanam J. Lalani (UCSF: University of California, San Francisco)H-Index: 3
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 39
view all 9 authors...
Abstract Cerebrovascular risk factors (CVRFs) and comorbid cardiovascular and metabolic disease have been linked to accelerated cognitive aging and dementia in the general population; however, the contribution of these comorbidities to the risk of post anterior temporal lobectomy (ATL) memory decline has been unexamined. We explored the effects of CVRFs on postoperative verbal memory decline in a cohort of 22 patients with left temporal lobe epilepsy (LTLE) who completed pre- and one-year postsu...
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#1Sanam J. Lalani (BYU: Brigham Young University)H-Index: 3
#2Tyler C. Duffield (BYU: Brigham Young University)H-Index: 9
Last. Janet E. Lainhart (UW: University of Wisconsin-Madison)H-Index: 46
view all 13 authors...
ABSTRACTStudies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typically developing individuals on standardized measures of attention, even when controlling for IQ. The current study sought to examine within ASD whether anatomical correlates of attention performance differed between those with average to above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in comparison to typically developing co...
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#1Sanam J. LalaniH-Index: 3
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