Wenwu Liu
Shenyang Pharmaceutical University
MCF-7Chemical synthesisIonotropic effectPhosphorylationCancerAdipogenesisInternal medicineEndocrinologyPathologyThermogenesisWhite adipose tissueNeuroscienceCognitionReceptorAdipose tissueHEK 293 cellsGSK-3ChemistryApoptosisIndole testStructure–activity relationshipIn vitroAutophagyIn vivoLipid dropletNeuroprotectionMetabotropic receptorCassiaCaffeoylquinic acidOxidative stressAmyloid betaWestern blotCimicifugaOkadaic acidPuerariaTyrosine phosphorylationDYRK1ACinnamomumAntioxidantEpilepsyHyperphosphorylationWortmanninCAMKAmidineTau proteinDiseaseMedicinal plantsNeurotoxicityLipoproteinTriple-negative breast cancerChlorogenic acidAMPKEugenolNotopterygium incisumBrown adipose tissueExcitotoxicityAntiparasiticHarmineTranscriptome SequencingArctium lappaIsolation techniquesNotopterolCytochrome cChemical dataTau pathologyNormal dietDual inhibitorAmyloid ßTotal synthesisMorris water navigation taskReactive oxygen speciesIon channelCancer researchBreast cancerHydrogen peroxideBiochemistryGlutamate receptorSignal transductionHomeostasisNMDA receptorComputational biologyText miningMedicineProtein kinase BThermogeninPI3K/AKT/mTOR pathwayNeuroinflammationCell biologyCancer cellEC50Pharmacology
13Publications
4H-index
36Citations
Publications 13
Newest
#1Xin Liu (SPU: Shenyang Pharmaceutical University)
#2Ya-ping Gao (SPU: Shenyang Pharmaceutical University)
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract null null Ethnopharmacological relevance null Cinnamomum cassia Presl (Rougui) has character of xin、gan、wen, belongs to Jing of heart、lung、bladder, and has the effect of dispersing cold and relieving pain. It is widely used to resolve the exterior and dissipate cold in Treatise on Febrile Diseases (Shang Han Lun), such as Chaihu Guizhi Ganjiang Tang and Guizhi Renshen Tang. Both these two prescriptions contain Cinnamomum cassia Presl and Zingiber officinale Rosc (Ganjiang). Rougui-Ganji...
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Abstract null null Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease, characterized by irreversible cognitive impairment, memory loss and behavioral disturbances, ultimately leading to death. Glycogen synthase kinase 3β (GSK-3β) and dual-specificity tyrosine phosphorylation regulated kinase1A (DYRK1A) have gained a lot of attention for its role in tau pathology. To search for potential dual GSK-3β/DYRK1A inhibitors, we focused on harmine, a natural β-carboline alkal...
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#1Hui Jia (SPU: Shenyang Pharmaceutical University)
#2Xin-Ying Wang (SPU: Shenyang Pharmaceutical University)H-Index: 1
Last. Jincai Lu (SPU: Shenyang Pharmaceutical University)H-Index: 14
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Abstract Ethnopharmacological relevance Cimicifuga dahurica (Turcz.) Maxim (C. dahurica) has a long history of treating breast cancer. From the Qing Dynasty to the Tang Dynasty and even earlier, C. dahurica has been documented in the treatment of breast carbuncle (Breast cancer is classified as breast carbuncle in Chinese medicine). In traditional prescriptions such as “Sheng Ge Decoction”, “Sheng Ma Powder” and “Breast Carbuncle Pill”, as the main medicine, C. dahurica plays an important role. ...
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#1Yue YangH-Index: 5
#2Huan Gao (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Abstract Background Arctium lappa L. roots are very popular cultivated vegetables, which possesses various pharmacological activities. Our previous studies have demonstrated that Arctium lappa L. roots exerted protective effects against H2O2, glutamate and N-methyl-D-aspartic acid (NMDA)-induced neuronal injury in vitro. However, whether Arctium lappa L. roots could prevent against cerebral ischemia and the underlying mechanism remain unclear. Purpose The objective of the present study was to in...
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#1Wenwu LiuH-Index: 4
#2Jingda LiH-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Caffeoylquinic acids (CQAs) are a broad class of secondary metabolites that have been found in edible and medicinal plants from various families. It has been 100 years since the discovery of chloro...
2 CitationsSource
#1Yue Yang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Ling-Yue Gao (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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Kukoamine (KuA) is a spermine alkaloid present in traditional Chinese medicine Cortex Lycii radices, which possesses various pharmacological properties. Our previous studies have demonstrated that KuA exerts neuroprotective effects against H2O2-induced oxidative stress, radiation-induced neuroinflammation, oxidative stress and neuronal apoptosis, as well as neurotoxin-induced Parkinson's disease through apoptosis inhibition and autophagy enhancement. The present study aimed to investigate the ne...
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#1Yue Yang (SPU: Shenyang Pharmaceutical University)H-Index: 5
#2Huan GaoH-Index: 2
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
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: Compound DCMQA (4, 5-O-dicaffeoyl-1-O-[4-malic acid methyl ester]-quinic acid) is a natural caffeoylquinic acid derivative isolated from Arctium lappa L. roots. Caffeoylquinic acid derivatives have been reported to possess neuroprotective effects through inhibiting oxidative stress and apoptosis in vitro. However, whether DCMQA exerts protective effects on N-methyl-D-aspartate (NMDA)-induced neurotoxicity and the underlying mechanism has not been elucidated. In this study, the results indicate...
2 CitationsSource
#1Huan GaoH-Index: 2
#2Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Qing-Chun ZhaoH-Index: 3
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Abstract Five undescribed caffeoylquinic acid derivatives (CQAs), along with fifteen known CQAs, were isolated from the roots of Arctium lappa L.(burdock). The chemical structures of compounds were determined using extensive spectroscopic analyses, including UV, IR, NMR and MS. Further in vitro bioactive investigation demonstrated the neuroprotective effects of these compounds against the neurotoxicity of hydrogen peroxide (H2O2) and N-methyl-D-aspartate (NMDA). 1,3,5-tri-O-caffeoylquinic acid a...
6 CitationsSource
#1Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Lu Hongyuan (PRC: China Medical University (PRC))H-Index: 1
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 9 authors...
1 CitationsSource
#1Wenwu Liu (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Xiaowen Jiang (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Qingchun Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 13
view all 9 authors...
Abstract l -glutamate is an excitatory neurotransmitter in the central nervous system (CNS), which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N-methyl-D-aspartate (NMDA) receptor is a ligand-gated ion channel belonging to the iGluRs family. Among NMDA receptor subtypes, GluN2B subtype plays a crucial role in CNS diseases. In this review, we summarize, classify and discuss the reports on GluN2B antagonists, published from the 1990s to 2020, to provide the ther...
4 CitationsSource