Laiba Jamshed
McMaster University
OffspringInternal medicineEndocrinologyFunction (biology)Vascular endothelial growth factor ATranscriptomeAnimal studiesChemistryAdverse effectNucleic acidTranscriptional regulationSerotoninOxidative stressInflammationTrophoblastAromatic hydrocarbonSmoking cessationProstaglandin E2DibenzothiophenePregnancyNeurotoxicityNicotineAngiogenesisNicotine replacement therapySteroidTryptophan MetabolismTrophoblast cellPlacental dysfunctionReceptor expressionTube formationSignallingPhysiologyPeripheralPharmacotherapyTestosteroneBiochemistryMedicineANGPTL4Cell biology
5Publications
2H-index
4Citations
Publications 6
Newest
#1Jade Wish (UM: University of Manitoba)
#2Patrique Bulloch (UM: University of Manitoba)H-Index: 2
Last. Gregg T. Tomy (UM: University of Manitoba)H-Index: 42
view all 10 authors...
Abstract null null The aim of this study was to determine the kynurenine (KYN) to tryptophan (TRP) ratio (KTR) in fish tissue to assess its usefulness as a biomarker of acute stress. Laboratory held rainbow trout (Oncorhynchus mykiss) were subjected to an acute stressor and KYN, TRP and cortisol were measured in liver and brain tissues at 4- and 48-h post-stress. The analytical method used to determine our analytes was based on lyophilization, and liquid-solid extraction followed by isotope dilu...
Source
#1Sergio Raez-Villanueva (McMaster University)H-Index: 3
#2Genevieve A. Perono (McMaster University)H-Index: 3
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 5 authors...
Worldwide demand for petroleum products has resulted in increased oil and gas activities in many countries. Conventional and unconventional oil and gas extraction, production, and transport lead to increased levels of petroleum-derived polycyclic aromatic hydrocarbons (PAHs) in the environment. PAH exposure has profound effects on reproduction by affecting pathways involved in placental trophoblast cell function and impairing normal placental development and function-key contributors to reproduc...
Source
#1Laiba Jamshed (McMaster University)H-Index: 2
#2Genevieve A. Perono (McMaster University)H-Index: 3
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 6 authors...
Source
#1Laiba JamshedH-Index: 2
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 4 authors...
Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal and developmental complications, as well as an increased risk of adverse health consequences in the adult offspring. Nicotine replacement therapy (NRT) and electronic nicotine delivery systems (e-cigarettes) have been developed as a pharmacotherapy for smoking cessation and are considered safer alternatives for women to smoke during pregnancy. The safety of NRT use during pregnancy has been evaluated in a limited n...
Source
#1Laiba Jamshed (McMaster University)H-Index: 2
#2Sergio Raez-Villanueva (McMaster University)H-Index: 3
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 5 authors...
Abstract There is considerable concern that naphthenic acids (NA) related to oil extraction can negatively impact reproduction in mammals, yet the mechanisms are unknown. Since placental dysfunction is central to many adverse pregnancy outcomes, the goal of this study was to determine the effects of NA exposure on placental trophoblast cell function. HTR-8/SVneo cells were exposed to a commercial technical NA mixture for 24 hours to assess transcriptional regulation of placentation-related pathw...
Source
#1Sergio Raez-Villanueva (McMaster University)H-Index: 3
#2Laiba Jamshed (McMaster University)H-Index: 2
Last. Alison C. Holloway (McMaster University)H-Index: 48
view all 6 authors...
ABSTRACT There is considerable concern that naphthenic acids (NA) related to oil extraction can negatively impact reproduction in mammals yet the mechanisms are unknown. Since placental dysfunction is central to many adverse pregnancy outcomes, the goal of this study was to determine the effects of NA exposure on placental trophoblast cell function. Htr8/SVneo cells were exposed to a commercial technical NA mixture (Sigma-Aldrich) for 24 hours to assess steroid production and markers of inflamma...
Source
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