Wei Li
Sichuan University
Biological activityCancerInternal medicineCalcitriol receptorChemistryMaterials scienceIn vitroIn vivoVitaminMelanomaCancer researchBiochemistryStereochemistryMedicineTubulinBiologyCancer cellPharmacology
281Publications
54H-index
8,133Citations
Publications 288
Newest
#1W B Li (QUST: Qingdao University of Science and Technology)H-Index: 6
Last. Stephan KabelacH-Index: 17
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#1Xiyu Li (Sichuan University)H-Index: 4
#2Qin Zou (Sichuan University)H-Index: 17
Last. Wei Li (Sichuan University)H-Index: 54
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Abstract null null Scaffold degradation regulation has become the key aspects in promoting bone regeneration and reconstruction. In the study, a novel stepwise-degraded PLGA/PCL/HA:Yb/Ho/Zn (PPHZ) scaffold was designed to compare with the fast-degradable PLGA/HA:Yb/Ho/Zn (PLHZ) scaffold to investigate the effects of scaffold degradation regulation on osteogenesis and to trace the scaffold degradation process. Micro-CT reconstruction, confocal fluorescence imaging, and histological sections were ...
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#1Wei Li (UT: University of Tennessee)H-Index: 54
#2Pritam Kumar Jana (GAU: University of Göttingen)H-Index: 5
Last. Manolis Doxastakis (UT: University of Tennessee)H-Index: 26
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#1Souvik Banerjee (University of Arkansas – Fort Smith)H-Index: 11
#2Foyez Mahmud (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Zhongzhi Wu (UTHSC: University of Tennessee Health Science Center)H-Index: 4
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Small molecules that interact with the colchicine binding site in tubulin have demonstrated therapeutic efficacy in treating cancers. We report the design, syntheses, and antitumor efficacies of new analogues of pyridopyrimidine and hydroquinoxalinone compounds with improved drug-like characteristics. Eight analogues, 5j, 5k, 5l, 5m, 5n, 5r, 5t, and 5u, showed significant improvement in metabolic stability and demonstrated strong antiproliferative potency in a panel of human cancer cell lines, i...
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#2Mohamed Ibrahim (UTHSC: University of Tennessee Health Science Center)H-Index: 45
Last. Monica M. JablonskiH-Index: 26
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Glaucoma is a leading cause of permanent vision loss and current drugs do not halt disease progression. Thus, new therapies targeting different drug targets with novel mechanisms of action are urgently needed. Previously, we identified CACNA2D1 as a novel modulator of intraocular pressure (IOP) and demonstrated that a topically applied CACNA2D1 antagonist—pregabalin (PRG)—lowered IOP in a dose-dependent manner. To further validate this novel IOP modulator as a drug target for IOP-lowering pharma...
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#1Monica L Brown Lobbins (UTHSC: University of Tennessee Health Science Center)H-Index: 1
#2Imara-Safi O. Scott (UTHSC: University of Tennessee Health Science Center)
Last. Tejesh Patel (UTHSC: University of Tennessee Health Science Center)H-Index: 4
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Systemic sclerosis (SSc; scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit D analog, 17,20S(OH)2pD, suppresses fibrosis and mediators of the TGF-β1 pathway in the bleomycin (BLM) model of fibrosis. Fibrosis was induced into the skin of female C57BL/6 mice by repeated injections of BLM (50 μg/100 μL) subcutaneously. Mice received ...
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#1Petra Bacova (FORTH: Foundation for Research & Technology – Hellas)H-Index: 5
#2Wei Li (UT: University of Tennessee)H-Index: 54
Last. Vagelis Harmandaris (FORTH: Foundation for Research & Technology – Hellas)H-Index: 31
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The dynamics of polymer chains in the polymer/solid interphase region have been a point of debate in recent years. Its understanding is the first step towards the description and the prediction of the properties of a wide family of commercially used polymeric-based nanostructured materials. Here, we present a detailed investigation of the conformational and dynamical features of unentangled and mildly entangled cis-1,4-polybutadiene melts in the vicinity of amorphous silica surface via atomistic...
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#6Yong Li (St. Jude Children's Research Hospital)H-Index: 7
We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the structure of CH-2-77 by blocking metabolically labile sites and synthesized a series of CH-2-77 analogues. Two compounds, 40a and 60c, preserved the potency while improving the metabolic stability over CH-2-77 by 3- to 4-fold (46.8 and 29.4 vs 10.8 min in human microsomes). We determined the high-resolution X-ray crystal structures of 40a (resolution 2.3 A) and 60c (resolution 2.6 A) in complex with tubuli...
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#1Kiran Kumar Reddi (University of Hyderabad)
#2Hanxuan Li (UTHSC: University of Tennessee Health Science Center)
Last. Sarada D. Tetali (University of Hyderabad)H-Index: 10
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Berberine (BBR), a plant alkaloid, is known for its therapeutic properties of anticancer, cardioprotective, antidiabetic, hypolipidemic, neuroprotective, and hepatoprotective activities. The present study was to determine the molecular mechanism of BBR’s pharmacological activity in human monocytic (THP-1) cells induced by arachidonic acid (AA) or lipopolysaccharide (LPS). The effect of BBR on AA/LPS activated proinflammatory markers including TNF-α, MCP-1, IL-8 and COX-2 was measured by ELISA or...
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#1Najah Albadari (UTHSC: University of Tennessee Health Science Center)H-Index: 2
#2Shanshan Deng (UTHSC: University of Tennessee Health Science Center)H-Index: 5
Last. Wei Li (UTHSC: University of Tennessee Health Science Center)H-Index: 54
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Abstract null null The survivin (BIRC5) expression is very low in normal differentiated adult tissues, but it is one of the most widely upregulated genes in tumor cells. The overexpression of survivin in many cancer types has been positively correlated with resistance to chemotherapy, tumor metastasis, and poor patient survival. Survivin is considered to be a cancer specific biomarker and serves as a potential cancer drug target. In this report, we describe the design and syntheses of a series o...
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