Xuguang Chen
Johns Hopkins University School of Medicine
Fluid-attenuated inversion recoveryRadiologyMagnetic resonance imagingEffective dose (radiation)Logistic regressionRadiological weaponMedical recordMyelopathyRadiomicsMetastasisContouringTumor progressionVertebral compression fractureMass indexMedian follow-upRadiosurgeryChordomaSpinal ChordomaSpine metastasisTransverse Spin Relaxation TimeRadiation necrosisProbability modelNuclear medicineSpinal metastasisStereotactic body radiotherapyEn bloc resectionSmoking statusIn patientTrabecular boneExternal validationNormal tissueMultivariate analysisConfidence intervalProportional hazards modelBrainstemMedicineCohortComplication
7Publications
2H-index
10Citations
Publications 10
Newest
#1Chengcheng Gui (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
#2Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
Last. Kristin J. Redmond (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 21
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OBJECTIVE In the treatment of spinal metastases with stereotactic body radiation therapy (SBRT), vertebral compression fracture (VCF) is a common and potentially morbid complication. Better methods to identify patients at high risk of radiation-induced VCF are needed to evaluate prophylactic measures. Radiomic features from pretreatment imaging may be employed to more accurately predict VCF. The objective of this study was to develop and evaluate a machine learning model based on clinical charac...
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#1Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Hanbo Chen (U of T: University of Toronto)H-Index: 9
Last. Umberto Ricardi (UNITO: University of Turin)H-Index: 52
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Background: Stereotactic body radiotherapy (SBRT) is increasingly used to treat oligometastatic disease (OMD), but the effect of metastasis timing on patient outcomes remains uncertain. Methods: An international database of patients with OMD treated with SBRT was assembled with rigorous quality assurance. Early versus late metastases were defined as those diagnosed ≤24 versus >24 months from the primary tumor. Overall survival (OS), progression-free survival (PFS), and incidences of wide-spread ...
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#1Xuguang ChenH-Index: 2
#2Sheng Fu L. LoH-Index: 15
Last. Kristin J. RedmondH-Index: 21
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Objective null Spinal chordoma is locally aggressive and has a high rate of recurrence, even after en bloc resection. Conventionally fractionated adjuvant radiation leads to suboptimal tumor control, and data regarding hypofractionated regimens are limited. The authors hypothesized that neoadjuvant stereotactic body radiotherapy (SBRT) may overcome its intrinsic radioresistance, improve surgical margins, and allow preservation of critical structures during surgery. The purpose of this study is t...
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#1Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Vishwa S. Parekh (Johns Hopkins University)H-Index: 9
Last. Lawrence Kleinberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 39
view all 8 authors...
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#1Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Chengcheng Gui (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
Last. Kristin J. Redmond (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 21
view all 9 authors...
OBJECTIVE Stereotactic body radiotherapy (SBRT) for spine metastases is associated with post-treatment vertebral compression fracture (VCF). The purpose of this study is to identify clinical and radiation planning characteristics that predict post-SBRT VCF through a novel normal tissue complication probability (NTCP) analysis. METHODS Patients with de novo spine metastases treated with SBRT between 2009 and 2018 at a single institution were included. Those who had surgical stabilization or radia...
5 CitationsSource
#1Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Vishwa S. Parekh (Johns Hopkins University)H-Index: 9
Last. Lawrence Kleinberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 39
view all 8 authors...
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#1Jeff EhresmanH-Index: 7
#2Andrew SchillingH-Index: 4
Last. Kristin J. RedmondH-Index: 21
view all 11 authors...
OBJECTIVE: Vertebral compression fractures (VCFs) in patients with spinal metastasis can lead to destabilization and often carry a high risk profile. It is therefore important to have tools that enable providers to predict the occurrence of new VCFs. The most widely used tool for bone quality assessment, dual-energy x-ray absorptiometry (DXA), is not often available at a patient's initial presentation and has limited sensitivity. While the Spinal Instability Neoplastic Score (SINS) has been asso...
9 CitationsSource
#1Xuguang Chen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Jimm Grimm (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
Last. Lawrence Kleinberg (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 39
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