Song Zhang
Shenyang Pharmaceutical University
Proinflammatory cytokineChemistryMyeloperoxidaseColitisActinidia argutaOxidative stressInflammationLipopolysaccharideDried fruitPharmacology
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In this study, we aimed at investigating the antiinflammatory activity of the freeze-dried fruit powder of Actinidia arguta (FAA) on dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice and the effect of its extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. For pharmacodynamic studies, the oral administration of FAA (300 or 600 mg kg−1) could decrease the disease activity index (DAI), reduce the incidence of colon and spleen edemas (caused by inflammation), a...
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