Ruilin Zhang
Guangzhou University of Chinese Medicine
Gene silencingInternal medicineEndocrinologymicroRNAVascular dementiaAntagomirDementiaOncogeneSynapsin IMedicineTranscription factor
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: Forkhead box P2 (Foxp2) is a transcription factor involved in vocal learning. However, the number of previous studies that have investigated the role of Foxp2 in early vascular dementia (VD) is limited. The aim of the present study was to determine whether microRNA (miR)‑134‑5p/Foxp2 contributes to cognitive impairment in a chronic ischemia‑induced early VD model. miR‑134‑5p was found to be significantly increased in the cortex in a rat VD model. Intracerebroventricular injection of miR‑134‑5p...
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