Xu You
China Three Gorges University
CellAndrologyChemistryGlial cell line-derived neurotrophic factorApoptosisStem cell factorWestern blotSeminiferous tubuleMalondialdehydeCaspase 12IcariinSertoli cellMitochondrionCell cycleCell morphologyNormal dietAgeingViability assayFlow cytometryBiology
5Publications
1H-index
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Publications 5
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#1Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
#2Xu You (CTGU: China Three Gorges University)H-Index: 1
Last. Ding Yuan (CTGU: China Three Gorges University)H-Index: 10
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Sertoli cells play crucial roles in spermatogenesis and are impaired by aging. Icariin, a flavonoid from Epimedium, has been reported to exhibit anti-aging effects and improve testicular dysfunction in the clinical setting. However, whether icariin improves age-related degeneration of testicular function via protection from Sertoli cell injury remains unclear. In the present study, we evaluated the protective effect of icariin on Sertoli cell injury and explored the possible mechanism(s) in vivo...
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#1Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
#2Na Ma (CTGU: China Three Gorges University)H-Index: 2
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
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Abstract Activation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) and mitochondrial apoptotic pathway serves as a central regulator for maintaining cell function and survival, and is associated with ageing and spermatogenesis. However, changes in UPR activation and mitochondrial apoptotic pathway in the testis during ageing remain unclear. In this study, we hypothesized that UPR activation declines and the mitochondrial apoptotic pathway is activated in the testis duri...
3 CitationsSource
#1Na Ma (CTGU: China Three Gorges University)H-Index: 2
#2Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
Last. Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
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: To study the protective effects of Wuzi Yanzong recipe on testis germ cell apoptosis in natural ageing rats through endoplasmic reticulum stress (ERS), 16-month-old male SPF grade SD rats were randomly divided into three groups: ageing model group, and low and high-dose Wuzi Yanzong recipe groups (WZ, 1 and 4 g·kg⁻¹), with 10 rats in each group. In addition, 2-month-old SD male rats were used as adult control group. The ageing model group and the adult control group were fed with normal diet f...
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#1Na Ma (CTGU: China Three Gorges University)H-Index: 2
#2Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
view all 8 authors...
To study the protective effects of Wuzi Yanzong recipe on DNA oxidative damage of testis germ cells in natural ageing rats based on Nrf2/HO-1 signaling pathway and base excision repair (BER). In the study, 16-month-old SPF grade male SD rats were randomly divided into three groups, namely ageing model group, and low and high-dose Wuzi Yanzong recipe groups (WZ, 1, 4 g·kg⁻¹). In addition, 2-month-old SD rats were used as adult control group (10 rats in each group). The ageing model group and the ...
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#1Qian Chen (CTGU: China Three Gorges University)H-Index: 1
#2Haixia Zhao (CTGU: China Three Gorges University)H-Index: 7
Last. Changcheng Zhang (CTGU: China Three Gorges University)H-Index: 12
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Objective To establish a model of decline in secretion of senescent TM4 cells in vitro induced by D-galactose (D-gal). Methods Different concentrations of D-Gal (25, 50, 100, 150, 200 and 250 mmol/L) were used to induce TM4 cell senescence. The viability of TM4 cells was detected by MTT assay. The cell cycle was analyzed by flow cytometry. The cell morphology was observed by light microscopy and the percentage of senescent cells was observed by senescence-associated β-galactosidase (SA-β-Gal) st...
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