Huachen Yu
Peking Union Medical College
Endothelial stem cellSurgeryCellGene knockdownApoptosisIn vivoSynovectomyHarris Hip ScoreBone graftingVascular endothelial growth factorBlood vesselFemoral headAngiogenesisIcariinGlucocorticoidPathogenesisTube formationCell growthOrthopedic surgeryMedicine
6Publications
2H-index
12Citations
Publications 6
Newest
#1Ju'an YueH-Index: 3
#2Huachen Yu (Peking Union Medical College)H-Index: 2
Last. Qidong Zhang (China-Japan Friendship Hospital)H-Index: 10
view all 7 authors...
Abstract Background The pathogenesis of osteonecrosis of the femoral head (ONFH) is unclear. Our previous study demonstrated that upregulated miR-335 in bone microvascular endothelial cells (BMECs) might be associated with the disease of steroid-induced ONFH. Here, we study the preventive effect of ICA on steroid-induced ONFH in rats. Method 90 rats were separated into three groups: control group, methylprednisolone (MPS) group, and MPS + Icariin (ICA) group. Four weeks later, histological analy...
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#1Wei Zuo (PKU: Peking University)H-Index: 3
#2Wan‐shou Guo (PKU: Peking University)H-Index: 1
Last. Qidong Zhang (China-Japan Friendship Hospital)H-Index: 10
view all 5 authors...
OBJECTIVE: Nontraumatic osteonecrosis of the femoral head (ONFH) is one of the most common diseases in orthopaedics. The damage to vascular endothelial (VE) cells caused by glucocorticoids (GC) has been reported as a possible mechanism of pathogenesis for ONFH. Junction-mediating and regulatory protein (JMY), originally identified as a p53 coactivator, plays prominent roles in the DNA damage response and in cell motility. This study aimed to discover the role of JMY in the pathogenesis of GC-ind...
2 CitationsSource
#1Huachen Yu (WMU: Wenzhou Medical College)
#1Huachen Yu (WMU: Wenzhou Medical College)H-Index: 2
Last. Qidong Zhang (China-Japan Friendship Hospital)H-Index: 10
view all 8 authors...
BACKGROUND: Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is closely associated with the dysfunction of the bone microvascular endothelial cells (BMECs). The present study investigated the angiogenic and apoptotic activity of the BMECs in glucocorticoid-induced ONFH. METHODS: This study enrolled a total of 12 patients, six of whom were assigned to the ONFH group whereas the other six served as the control group. The ONFH group was composed of patients with glucocorticoid-induce...
2 CitationsSource
#1Pei Liu (Beijing University of Chinese Medicine)H-Index: 2
#2Xiao-Hong Mu (Beijing University of Chinese Medicine)H-Index: 2
Last. Wanshou Guo (China-Japan Friendship Hospital)H-Index: 14
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BACKGROUND: Non-vascularized bone grafting is a promising head-preserving technique for younger patients diagnosed as non-traumatic osteonecrosis of the femoral head (NONFH). Among the various types of bone grafting techniques, "light-bulb" procedure grafting with synthetic bone substitute is an attractive option. We aimed to assess the effectiveness of using beta-tricalcium phosphate (beta-TCP) for the treatment of pre-collapse and early post-collapse lesions NONFH. METHODS: From April 2010 to ...
3 CitationsSource
#1Huachen YuH-Index: 2
#2Ju’an Yue (PRC: China Medical University (PRC))H-Index: 1
Last. Qidong Zhang (China-Japan Friendship Hospital)H-Index: 10
view all 7 authors...
: The injury and dysfunction of the femoral head microvascular endothelial cells are associated with the pathogenesis of glucocorticoid-induced osteonecrosis of the femoral head (ONFH). Reports indicate that icariin (ICA) can enhance vascular roles and also inhibit endothelial cell dysfunction. However, it still remains unclear whether ICA can promote angiogenesis in glucocorticoid-induced ONFH. In this study, we investigate this hypothesis through in vitro and in vivo experiments. Results showe...
5 CitationsSource
#1Pei Liu (Beijing University of Chinese Medicine)H-Index: 2
#2Feifan Lu (PKU: Peking University)H-Index: 2
Last. Wanshou Guo (China-Japan Friendship Hospital)H-Index: 14
view all 8 authors...
During primary total knee arthroplasty (TKA), synovectomy as a part of the procedure has been recommended to relieve pain and inflammation of the synovium, but there is a controversy about it due to increased bleeding. In this meta-analysis, the aim is to answer whether synovectomy should be performed routinely during TKA for symptomatic knee osteoarthritis (KOA). Relevant randomized controlled trials (RCTs) on synovectomy were retrieved through database searches of PubMed, Embase, Web of Scienc...
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