Hongyuan Xu
Shanghai Jiao Tong University
Cathepsin KOsteocalcinConditional gene knockoutSTAT proteinKnockout mouseChemistryIn vitroIn vivoOsteoclastOsteoblastSTAT3Bone marrowIcariinWhole Bone MarrowGene Knockout TechniquesCancer stem cellGene knockoutBlotBiologyCell biology
6Publications
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20Citations
Publications 6
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#1Xiangru HuangH-Index: 2
#2Anting JinH-Index: 2
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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#1Yueyang HongH-Index: 3
#2Hongyuan XuH-Index: 2
Last. Lingyong JiangH-Index: 8
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#1Xinyi Gong (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Xiangru HuangH-Index: 2
Last. Lingyong JiangH-Index: 8
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#1Yiling YangH-Index: 4
#2Qianye ChenH-Index: 1
Last. Lingyong JiangH-Index: 8
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Transgenic mouse models are powerful for understanding the critical genes controlling osteoclast differentiation and activity, and for studying mechanisms and pharmaceutical treatments of osteoporosis. Cathepsin K (Ctsk)-Cre mice have been widely used for functional studies of osteoclasts. The signal transducer and activator of transcription 3 (STAT3) is relevant in bone homeostasis, but its role in osteoclasts in vivo remains poorly defined. To provide the in vivo evidence that STAT3 participat...
1 CitationsSource
#1Hongyuan Xu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Siru Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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OBJECTIVES: Alveolar bone osteoporosis has attracted more and more attention because of its profound impact on stomatognathic function and treatment, but current treatments have not been targeted to alveolar bone and might even cause severe side effects. Thus, identifying the effects of anti-osteoporosis agents on alveolar bone is essential. Icariin ameliorates metabolic dysfunction of long bones, but its effects on alveolar bone remain unclarified. MATERIALS AND METHODS: BMSCs were isolated fro...
6 CitationsSource
#1Yiling Yang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Mi Ri Chung (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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: The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a central role in cell survival and function. STAT3 has been demonstrated to participate in the maintenance of bone homeostasis in osteoblasts, but its role in osteoclasts in vivo remains poorly defined. Here, we generated a conditional knockout mouse model in which Stat3 was deleted in osteoclasts using a cathepsin K-Cre (Ctsk-Cre) driver. We observed that osteoclast-specific Stat3 deficiency caused incr...
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