Deepshikha Shahdeo
Linear rangeAnalyteColloidal goldContaminationSurface modificationDetection limitPrinted circuit boardQuantum dotAptamerFabricationNanomaterialsSurface-area-to-volume ratioDynamic light scatteringAdsorptionNanoparticleVirologyBiosensorNanoprobeVitronectinNanotechnologyElectrodeChemistryMaterials scienceCell surface receptorVirusPeptideDrug deliveryPotentiostatSensitivity (electronics)Somatomedin BTin oxideNanoconjugatesBiosensor deviceHuman healthAvian influenza virusStandard bufferSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)GrapheneCovalent bindingRapid detectionVirus isolationSpecific detectionAflatoxinChromatographyOptoelectronicsBiomoleculeElectrochemistryBiochemistryUrokinase receptorMicrofluidicsBiology
9Publications
4H-index
119Citations
Publications 9
Newest
#1Deepshikha ShahdeoH-Index: 4
#2Veerbhan KesarwaniH-Index: 1
Last. Sonu GandhiH-Index: 19
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Abstract Targeting cell surface receptors for specific drug delivery in cancer has garnered lot of attention. Urokinase plasminogen activator receptor (uPAR), a surface biomarker, is overexpressed on many tumours including breast, colorectal, prostate, and ovarian cancers. Binding of growth factor domain (GFD) of urokinase plasminogen activator (uPA) with uPAR lead to its close conformation, and allow somatomedin B domain (SMB) of vitronectin binding by allosteric modulation. In-silico docking o...
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#1Akanksha RobertsH-Index: 3
#2Deepshikha ShahdeoH-Index: 4
Last. Sonu GandhiH-Index: 19
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Immobilization techniques involve the confining/anchoring of a molecule (enzyme or cells) in or on an inert support/substrate matrix for stability, increased efficiency and easy recoverability of the molecule. The immobilization of molecules to a substrate is carried out on the basis of five major principle methods, i.e. adsorption, entrapment, membrane confinement (encapsulation), cross-linking (copolymerization) and covalent binding. Various different scientific processes make use of immobiliz...
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#1Aruna Kasoju (Jawaharlal Nehru Technological University, Anantapur)H-Index: 2
#2Deepshikha ShahdeoH-Index: 4
Last. Sonu GandhiH-Index: 19
view all 9 authors...
1 CitationsSource
#1Subhasis MahariH-Index: 3
#2Akanksha RobertsH-Index: 3
Last. Sonu GandhiH-Index: 19
view all 4 authors...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, also known as 2019-nCov or nCovid-19) outbreak has become a huge public health issue due to its rapid transmission making it a global pandemic. Currently, there are no vaccines or drugs available for nCovid-19, hence early detection is crucial to help and manage the outbreak. Here, we report an in-house built biosensor device (eCovSens) and compare it with a commercial potentiostat machine for the detection of nCovid-19 spike protein a...
41 CitationsSource
#1Subhasis MahariH-Index: 3
#2Akanksha RobertsH-Index: 3
Last. Sonu GandhiH-Index: 19
view all 4 authors...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, also known as 2019-nCov or nCovid-19) outbreak has become a huge public health issue due to its rapid transmission making it a global pandemic. Currently, there are no vaccines or drugs available for nCovid-19, hence early detection is crucial to help and manage the outbreak. Here, we report an in-house built biosensor device (eCovSens) and compare it with a commercial potentiostat machine for the detection of nCovid-19 spike ...
39 CitationsSource
#1Aruna Kasoju (Jawaharlal Nehru Technological University, Anantapur)H-Index: 2
Last. Sonu GandhiH-Index: 19
view all 6 authors...
Contamination of milk by mycotoxins is a serious problem worldwide. Herein, we focused on the detection of aflatoxin B1 (AflB1) using a paper microfluidic device fabricated with specific aptamers as biorecognition elements. The fabrication process resulted in the generation of a leak proof microfluidic device where two zones were designed: control and test. Detection is achieved by color change when aflatoxin reacts with an aptamer followed by salt induced aggregation of gold nanoparticles. Spec...
10 CitationsSource
#1Aruna Kasoju (Jawaharlal Nehru Technological University, Anantapur)H-Index: 2
#2Deepshikha ShahdeoH-Index: 4
Last. Sonu GandhiH-Index: 19
view all 9 authors...
This study describes the colorimetric detection of aflatoxin M1 (Afl M1) in milk samples using a microfluidic paper-based analytical device (µPAD). Fabrication of µPADs was done using a simple and quick approach. Each μPAD contained a detection zone and a sample zone interconnected by microchannels. The colorimetric assay was developed using unmodified AuNPs as a probe and 21-mer aptamer as a recognition molecule. The free aptamers were adsorbed onto the surface of AuNPs in absence of Afl M1, ev...
11 CitationsSource
#1Deepshikha ShahdeoH-Index: 4
#2Akanksha RobertsH-Index: 3
Last. Sonu GandhiH-Index: 19
view all 4 authors...
Abstract The two dimensional, honeycomb structured, single carbon layered graphene has extensively been used in the field of sensor detection due to its unique physicochemical properties. These properties such as excellent electrical conductivity, high electron mobility, tunable optical properties, room temperature quantum Hall effect, large surface to volume ratio, high mechanical strength, and ease of functionalization, make it an ideal nanomaterial for sensor development. This has enabled the...
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#1Ivneet BangaH-Index: 5
#2R. K. TyagiH-Index: 4
Last. Sonu GandhiH-Index: 19
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Abstract Avian influenza virus (AIV), a type A influenza virus, has been infecting an increasingly large number of poultry each year and poses a serious threat to the human health. Conventional diagnostic techniques such as virus isolation and sequencing, immunohistochemical assays, and enzyme-linked immunosorbent assay are time-consuming, require trained personnel and expensive equipment, and are not suitable for on-site detection. Advancements in the field of biosensors technology have paved w...
1 CitationsSource