Martyna Sochacka
University of Wrocław
EndosomeBinding siteCytotoxicityProtein–protein interactionInternalizationCytoskeletonMutantAntigenCell signalingCytotoxic T cellChemistryFGF1IntegrinConjugateDrug deliveryFibroblastExtracellularNucleocytoplasmic TransportIntegrin bindingSecretionPlasma protein bindingFlow cytometryCell growthSignal transductionFibroblast growth factorIntracellularFibroblast growth factor receptorCell divisionCell biologyCancer cell
Publications 5
#1Marta Poźniak (UWr: University of Wrocław)
#2Natalia Porębska (UWr: University of Wrocław)H-Index: 3
Last. Łukasz Opaliński (UWr: University of Wrocław)H-Index: 7
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BACKGROUND Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs to the cancer cells using ADCs specific for tumor-associated antigens enables sparing the healthy cells and thereby reduces unwanted side effects. Overexpression of fibroblast growth factor receptor 1 (FGFR1) has been demonstrated in numerous tumors and thereby constitutes a convenient molecular target for selective cancer trea...
#1Katarzyna Dominika Sluzalska (UWr: University of Wrocław)H-Index: 1
#2Jakub Sławski (UWr: University of Wrocław)H-Index: 3
Last. Malgorzata Zakrzewska (UWr: University of Wrocław)H-Index: 17
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Abstract Fibroblast growth factors 1 and2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are able to translocate from the endosome to the cell interior. These unique features, as well as the role of the intracellular pool of FGF1 and FGF2, are far from being fully understood. An increasing number of reports address this problem...
2 CitationsSource
#1Martyna SochackaH-Index: 2
#2Lukasz OpalinskiH-Index: 3
Last. Malgorzata ZakrzewskaH-Index: 17
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#1Martyna Sochacka (UWr: University of Wrocław)H-Index: 2
#2Lukasz Opalinski (UWr: University of Wrocław)H-Index: 3
Last. Malgorzata Zakrzewska (UWr: University of Wrocław)H-Index: 17
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Fibroblast growth factors (FGFs) via their receptors (FGFRs) transduce signals from the extracellular space to the cell interior, modulating pivotal cellular processes such as cell proliferation, motility, metabolism and death. FGF superfamily includes a group of fibroblast growth factor homologous factors (FHFs), proteins whose function is still largely unknown. Since FHFs lack the signal sequence for secretion and are unable to induce FGFR-dependent cell proliferation, these proteins were cons...
5 CitationsSource
#1Anna Szlachcic (UWr: University of Wrocław)H-Index: 10
#2Martyna Sochacka (UWr: University of Wrocław)H-Index: 2
Last. Malgorzata Zakrzewska (UWr: University of Wrocław)H-Index: 17
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Fibroblast growth factor 1 (FGF1) has been shown to interact with integrin αvβ3 through a specific binding site, involving Arg35 residue. The FGF1 mutant (R35E) with impaired integrin binding was found to be defective in its proliferative response, although it was still able to interact with FGF receptors (FGFR) and heparin and induce the activation of downstream signaling pathways. Here, we demonstrate that the lack of mitogenic potential of R35E mutant is directly caused by its decreased therm...
3 CitationsSource