Yan Chen
Sichuan University
Genetic enhancementAcute toxicityCancerInternal medicineDownregulation and upregulationMultiple drug resistanceNuclear chemistryOncologyCytotoxic T cellNanoparticleIntensive care medicineChemistryApoptosisIn vitroAutophagyIn vivoChemotherapyCombination therapyPaclitaxelSorafenibGrowth inhibitionDrugCell cycleToxicityReactive oxygen speciesCancer researchPolymerPEDFColorectal cancerBreast cancerMedicineProtein kinase BA549 cellPI3K/AKT/mTOR pathwayBiologyCRISPRPharmacology
20Publications
9H-index
200Citations
Publications 20
Newest
#1Bingjie Zhou (Sichuan University)H-Index: 2
#2Min Li (Sichuan University)
Last. Shiqi Huang (Sichuan University)H-Index: 4
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Breast cancer was the leading cause of newly diagnosed cases of tumors in 2020, ranking as the second highest cause of female death. Chemotherapy remains the conventional treatment of choice for breast tumors in most clinical cases. However, it is often accompanied by a poor prognosis and severe side effects, resulting from an insufficient accumulation of the drug at tumor sites and an unsystematic distribution of the drug across the body. Inspired by the fact that breast tumor cells overexpress...
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#1Zhi LiaoH-Index: 1
#2Yan ChenH-Index: 9
Last. Hongtao XiaoH-Index: 3
view all 7 authors...
Abstract: In order to improve the effect of hydroxychloroquine (HCQ) on the selectivity in anti-tumour therapy, the α-linolenic acid conjugated hydroxychloroquine (AHQ) was designed, which was aiming to enhance anti-tumor effect. Basing on the in vitro data of AHQ, we chose colon cancer as the model disease. Herein, we assumed the combined therapy with 5-fluorouracil(5-Fu), which was the corner-stone on the treatment of colon cancer. After the successful synthesis, aqueous solubility, stability ...
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#1Jiayang Liu (Sichuan University)H-Index: 3
#2Zhao Huang (Sichuan University)H-Index: 12
Last. Canhua Huang (Sichuan University)H-Index: 52
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Poorly differentiated colorectal cancer (CRC) is characterized by aggressive invasion and stromal fibroblast activation, which results in rapid progression and poor therapeutic consequences. However, the regulatory mechanism involved remains unclear. Here, we showed that ZNF37A, a member of KRAB-ZFP family, was upregulated in poorly differentiated CRCs and associated with tumor metastasis. ZNF37A enhanced the metastatic potential of multiple CRC cell lines and promoted distant metastasis in an o...
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#1Z. Liu (University of Electronic Science and Technology of China)
#2Z. Liao (Academy of Medical Sciences, United Kingdom)
Last. H. Xiao (University of Electronic Science and Technology of China)
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Cancer is a serious public health problem in the world and the prevention and control of cancer has become one of the health strategies of governments around the world. According to the data of the International Agency for Research on Cancer (IARC), about 8 million people die of cancer every year in the world. With the continuous progress of medical technology, there are many methods to treat cancer at present. However, many treatment methods have achieved different therapeutic effects, some of ...
2 CitationsSource
#1Yan ChenH-Index: 9
Last. Hongtao XiaoH-Index: 3
view all 7 authors...
Imatinib mesylate (IM) is the standard treatment for advanced, metastatic gastrointestinal stromal tumors (GISTs) and chronic myeloid leukemia (CML) with a fixed daily standard dosage via the oral route. Interindividual and intraindividual variability in plasma concentrations have been closely linked to the efficacy of IM therapy. Therefore, this review identifies and describes the key factors influencing the plasma concentration of IM in patients with GISTs and CML. We used the following keywor...
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#1zhixi liuH-Index: 1
#2Zhi LiaoH-Index: 1
Last. Hongtao XiaoH-Index: 3
view all 6 authors...
Abstract:In the 1960 of the 20th century, scientists firstly advanced the concept of using gene therapy to cure the human genetic disease, which aimed to carry out precisely site-specific modification on the genome for obtain long-term therapeutic effect in patients. In the next 50 years, scientists have developed many new gene editing technologies including zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindrom...
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#1Can Bai (CDUTCM: Chengdu University of Traditional Chinese Medicine)
#2Zhe Zhang (Sichuan University)H-Index: 6
Last. Yong Tang (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 17
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Effective chemotherapy drugs for colorectal cancer remain a challenge. In this research, Ziyuglycoside II (Ziyu II), exhibits considerable antitumor activity against CRC cells both in vitro and in vivo. The results showed that Ziyu II induced apoptosis through the accumulation of reactive oxygen species (ROS), which was necessary for Ziyu II to inhibit colorectal cancer cells. Intriguingly, The treatment of Ziyu II triggered complete autophagic flux in CRC cells. Inhibition of autophagy partiall...
3 CitationsSource
#1Yan Chen (University of Electronic Science and Technology of China)H-Index: 9
#2TaiPeng Shen (University of Electronic Science and Technology of China)H-Index: 1
Last. Hongtao Xiao (University of Electronic Science and Technology of China)H-Index: 3
view all 8 authors...
In December 2019, a severe outbreak of a novel coronavirus (COVID-19) occurred in the whole world, posing a great threat to people's health. With the outbreak and development of the epidemic, how to improve the cure rate, find effective drugs against this virus, has been the most urgent problem. Chloroquine (CQ) was verified effective against COVID-19 in vitro. As CQ's analogue, hydroxychloroquine (HCQ) was also reminded as a potential candidate for treating COVID-19. This review summarizes the ...
8 CitationsSource
#1zhixi liu (CAS: Chinese Academy of Sciences)H-Index: 1
#2Zhi Liao (Academy of Medical Sciences, United Kingdom)H-Index: 1
Last. Hongtao Xiao (CAS: Chinese Academy of Sciences)H-Index: 3
view all 6 authors...
As gene-editing technology has become more and more popular in the life sciences, CRISPR has brought good news to scientific researchers because of its efficiency, convenience, and wide application. Its wide application has also promoted the development of basic scientific research, agriculture, basic medicine, and clinical treatment. However, how the CRISPR/dCas9 system is effectively delivered to the target organs or cells is still unknown. This paper briefly introduces the CRISPR/dCas9 system...
1 CitationsSource
#1Ningxi Li (Chengdu Medical College)H-Index: 4
#2Yan Chen (University of Electronic Science and Technology of China)H-Index: 9
Last. Min Wu (Chengdu Medical College)H-Index: 4
view all 9 authors...
Objective: A polymer-based nanoparticle was constructed to target sorafenib delivery to colorectal carcinoma cells and decrease the side effects of the drug.Methods: Sorafenib-loaded nanoparticles (S-NPs) based on PEG-PLGA were prepared using a double emulsion solvent evaporation method. The properties of S-NPs were evaluated and then their effects on the viability of colorectal cancer cells and normal human cells were assessed. The mechanism of S-NP internalization was explored using cellular u...
4 CitationsSource