Meiling Zhu
Guangzhou University of Chinese Medicine
Therapeutic effectStress granuleGene silencingInternal medicineGPX4Tyrosine hydroxylaseGene knockdownChemistryApoptosisIn vivoNeuroprotectionMoxibustionIdiopathic pulmonary fibrosisParkinson's diseaseSuper-enhancerFTH1Programmed cell deathReactive oxygen speciesCancer researchViability assaySignal transductionMedicineBiologyMechanism (biology)Cell biologyPharmacology
12Publications
4H-index
28Citations
Publications 13
Newest
Acute-on-chronic liver failure (ACLF) has been a hot spot in the field of liver disease research in recent years, with high morbidity, rapid course change and high mortality. Currently, there is the absence of specific treatment in clinical practice. Liver transplantation has the best therapeutic effect, but it is prone to have internal environment disorder and liver cell death after transplantation, which leads to the failure of transplantation.In recent years, with the development of molecular...
Source
Abstract null null Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide. Recent studies revealed that the ferroptosis pathway is involved in the death process of dopaminergic neurons in PD. The aberrant endosomal sorting pathway, which results in aberrant iron level in eukaryotic cells, may serve a role in the ferroptosis pathway in PD condition. However, its specific molecular mechanisms remained unclear. In the present study, we performed chromatin immunopr...
Source
#1Yichun Ji (Guangzhou University of Chinese Medicine)
#2Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
view all 9 authors...
ABSTRACT null null Ethnopharmacological relevance null Niujiaodihuang Detoxify Decoction (NDD) is an integrated traditional Chinese medicine prescription that has been used as a therapeutic agent for the treatment of acute liver failure (ALF). However, the mechanisms underlying its action remain unclear. null Aim of the study: To determine the protective effect of NDD on D-galactosamine/lipopolysaccharide (D-GalN/LPS)-induced ALF and explore the underlying mechanisms. null null null Materials an...
Source
#1Hang LiH-Index: 3
#2Caiping ZhaoH-Index: 3
Last. Meiling ZhuH-Index: 4
view all 9 authors...
Abnormal fibroblast differentiation into myofibroblast is a crucial pathological mechanism of pulmonary fibrosis (PF). Super-enhancers, a newly discovered cluster of regulatory elements, are regarded as the regulators of cell identity. We speculate that abnormal activation of super-enhancers must be involved in the pathological process of PF. This study aims to identify potential pathogenic super-enhancer-driven genes in PF. Differentially expressed genes (DEGs) in PF mouse lungs were identified...
Source
#1Zifeng Huang (Guangzhou University of Chinese Medicine)
Last. Meiling ZhuH-Index: 4
view all 9 authors...
Ferroptosis is associated with neural degeneration of dopaminergic neurons in Parkinson’s disease (PD). However, how to control the level of ferroptosis in PD remains unclear. Clinically, moxibustion has been used to treat PD and has an apparent therapeutic effect on improving the motor symptoms of PD. In the present study, the PD rat model was constructed by two-point stereotactic 6-hydroxydopamine injection. Then, moxibustion was used to treat the PD rats. The expression of glutathione peroxid...
Source
#2Yichun Ji (Guangzhou University of Chinese Medicine)
Last. Weihong KuangH-Index: 3
view all 8 authors...
Abstract In 1954, the term "probiotics" was coined by Ferdinand Vergin in his article. Although there are many clinical reports on the use of pro/synbiotics and other microbial preparations to prevent postoperative infections and related complications in patients with Colorectal cancer (CRC), their effectiveness remains divided. Therefore, we collected relevant high-quality randomized controlled trial (RCT) studies and conducted systematic review and meta-analysis. We electronically searched onl...
Source
#1Xinrong LiH-Index: 2
#2Wenwen SiH-Index: 4
Last. Meiling ZhuH-Index: 4
view all 12 authors...
Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN). In a previous study, the authors demonstrated that ferritin heavy chain 1 (FTH1) inhibited ferroptosis in a model of 6‑hydroxydopamine (6‑OHDA)‑induced PD. However, whether and how microRNAs (miRNAs/miRs) modulate FTH1 in PD ferroptosis is not yet well understood. In the present study, in vivo and in vitro models of PD induced by 6‑OHDA were establishe...
Source
#1Ye Tian (Guangzhou University of Chinese Medicine)H-Index: 3
#2Juan Lu (Southern Medical University)H-Index: 1
Last. Meiling Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
view all 11 authors...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons associated with dysregulation of iron homeostasis in the brain. Ferroptosis is an iron-dependent cell death process that serves as a significant regulatory mechanism in PD. However, its underlying mechanisms are not yet fully understood. By performing RNA sequencing analysis, we found that the main iron storage protein ferritin heavy chain 1 (FTH1) is differentially expressed in the rat...
10 CitationsSource
#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Zhen Li (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Meiling Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
view all 9 authors...
As a sensitive cold-shock protein, RNA binding protein motif 3 (RBM3) exhibits a neuroprotective function in the condition of brain injury. However, how RBM3 is involved in acute ischemic stroke by affecting stress granules (SGs) remains unclear. Here, we established an oxygen-glucose deprivation/reperfusion (OGD/R) model in rat primary cortical neurons and PC12 cells to explore the potential mechanism between RBM3 and SG formation in acute ischemic/reperfusion (I/R) condition. The immunofluores...
Source
#1Caiping ZhaoH-Index: 3
#2Hang LiH-Index: 3
Last. Meiling ZhuH-Index: 4
view all 8 authors...
1 CitationsSource