Sachi Okuchi
UCL Institute of Neurology
Intraclass correlationInterquartile rangeBiomedical engineeringSaturation (chemistry)Magnetic resonance imagingHyperintensityConcordanceSaturation (magnetic)ChemistryField strengthMaterials scienceIn vivoIsocitrate dehydrogenaseGrey matterGliomaScannerLesionWhite matterSignal SensitivityNuclear medicineRelaxation rateGlucose infusionSaturation transferChemical exchangeSignificant differenceBody regionConfidence intervalNuclear magnetic resonanceReceiver operating characteristicEffective diffusion coefficientMedicine
Publications 4
#1John MaynardH-Index: 3
#1John MaynardH-Index: 1
Last. Stefanie ThustH-Index: 7
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Background A readily implemented MRI biomarker for glioma genotyping is currently lacking. Purpose To evaluate clinically available MRI parameters for predicting isocitrate dehydrogenase (IDH) status in patients with glioma. Materials and Methods In this retrospective study of patients studied from July 2008 to February 2019, untreated World Health Organization (WHO) grade II/III gliomas were analyzed by three neuroradiologists blinded to tissue results. Apparent diffusion coefficient (ADC) mini...
10 CitationsSource
#1Mina Kim (UCL: University College London)H-Index: 3
#2Aaron Kujawa (UCL: University College London)H-Index: 3
Last. Xavier Golay (UCL: University College London)H-Index: 60
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PURPOSE: To translate the recently developed PRO-QUEST (Progressive saturation for quantifying exchange rates using saturation times) sequence from preclinical 9.4T to 3T clinical magnetic field strength. METHODS: Numerical simulations were performed to define the optimal saturation flip angles for PRO-QUEST saturation pulses at 3T and demonstrate the effect of a T2 error on the exchange rate (kex ) estimation at various field strengths. Exchange-dependent relaxation rate (Rex ) was measured for...
1 CitationsSource
#1Mina Kim (UCL: University College London)H-Index: 3
#2F Torrealdea (UCLH: University College Hospital)H-Index: 1
Last. Xavier GolayH-Index: 60
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Background: The aim of this study was to translate dynamic glucose enhancement (DGE) body magnetic resonance imaging (MRI) based on the glucose chemical exchange saturation transfer (glucoCEST) signal to a 3 T clinical field strength. Methods: An infusion protocol for intravenous (i.v.) glucose was optimised using a hyperglycaemic clamp to maximise the chances of detecting exchange-sensitive MRI signal. Numerical simulations were performed to define the optimum parameters for glucoCEST measureme...
8 CitationsSource
Last. Xavier GolayH-Index: 60
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