Yuying Tan
Boston University
Visible spectrumFrizzledIrradiationBiophysicsWnt signaling pathwayMicroscopyCellRaman scatteringChemistryMaterials scienceLipid dropletTumor initiationLaser ablationOvarian cancerStem cellSilver nanoparticleCancer researchChemical imagingMicroscopeCancer cell
19Publications
5H-index
88Citations
Publications 19
Newest
#1Jing Li (NU: Northwestern University)H-Index: 11
#1Junjie Li (NU: Northwestern University)
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Increased aerobic glycolysis is widely considered as a hallmark of cancer. Yet, cancer cell metabolic reprograming during development of therapeutic resistance is under-studied. Here, through high-throughput stimulated Raman scattering imaging and single cell analysis, we found that cisplatin-resistant cells exhibit increased uptake of exogenous fatty acids, accompanied with decreased glucose uptake and de novo lipogenesis, indicating a reprogramming from glucose and glycolysis dependent to fatt...
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#1Yi ZhangH-Index: 2
#1Yi ZhangH-Index: 2
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron spatial resolution and enables infrared spectroscopy and imaging of living cells and organisms. Yet, current mid-infrared photothermal imaging sensitivity suffers from a weak dependance of scattering on temperature and the image quality is vulnerable to the spe...
#1Haonan Lin (BU: Boston University)H-Index: 6
#2Yuying Tan (BU: Boston University)H-Index: 5
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 4 authors...
Hyperspectral stimulated Raman scattering (hSRS) is a label-free microspectroscopic modality that enables live-cell metabolic imaging with chemical specificity. Yet, hSRS in the CH region has low throughput and poor chemical specificity, which limits its application to a broader range of metabolic studies. We propose a high-content, high-throughput hSRS imaging method by a sparsity-driven spectral unmixing and active spectral sub-sampling. We unprecedently generate chemical maps of four major me...
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#1Peng Lin (BU: Boston University)H-Index: 6
#2Hongli Ni (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 7 authors...
Stimulated Raman scattering (SRS) microscopy enables the imaging of molecular events on a human subject in vivo, such as filtration of topical drugs through the skin and intraoperative cancer detection. A typical approach for volumetric SRS imaging is through piezo scanning of an objective lens, which often disturbs the sample and offers a low axial scan rate. To address these challenges, we have developed a deformable mirror-based remote-focusing SRS microscope, which not only enables high-qual...
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#1Suneel KumarH-Index: 18
#2Yuying TanH-Index: 5
Last. Francois BerthiaumeH-Index: 53
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Pressure ulcers (PUs) or sores are a secondary complication of diabetic neuropathy and traumatic spinal cord injury (SCI). PUs tend to occur in soft tissues located around bony prominences and may heal slowly or not at all. A common mechanism underlying impaired healing of PUs may be dysfunction of the local neurovascular system including deficiency of essential neuropeptides, such as substance P (SP). Previous studies indicate that disturbance in cutaneous sensory innervation leads to a defect ...
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#1Minghua Zhuge (ZJU: Zhejiang University)H-Index: 1
#2Kai-Chih Huang (BU: Boston University)H-Index: 8
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 11 authors...
High-sensitivity chemical imaging offers a window to decipher the molecular orchestra inside a living system. Based on vibrational fingerprint signatures, coherent Raman scattering microscopy provides a label-free approach to map biomolecules and drug molecules inside a cell. Yet, by near-infrared (NIR) pulse excitation, the sensitivity is limited to millimolar concentration for endogenous biomolecules. Here, the imaging sensitivity of stimulated Raman scattering (SRS) is significantly boosted f...
1 CitationsSource
#1Yinu Wang (NU: Northwestern University)H-Index: 4
#1Yinu Wang (NU: Northwestern University)H-Index: 8
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 14 authors...
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to parental cells. Add...
5 CitationsSource
#1Peng Lin (BU: Boston University)H-Index: 6
#2Hongli Ni (BU: Boston University)H-Index: 1
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 8 authors...
Operable under ambient light and providing chemical selectivity, stimulated Raman scattering (SRS) microscopy opens a new window for imaging molecular events on a human subject, such as filtration of topical drugs through the skin. A typical approach for volumetric SRS imaging is through piezo scanning of an objective lens, which often disturbs the sample and offers a low axial scan rate. To address these challenges, we have developed a deformable mirror-based remote-focusing SRS microscope, whi...
2 CitationsSource
#1Jing ZhangH-Index: 1
#2Jian Zhao (BU: Boston University)H-Index: 10
Last. Ji-Xin ChengH-Index: 83
view all 5 authors...
Hyperspectral stimulated Raman scattering (SRS) by spectral focusing can generate label-free chemical images through temporal scanning of chirped femtosecond pulses. Yet, pulse chirping decreases t...
4 CitationsSource
#1Yinu Wang (NU: Northwestern University)H-Index: 8
#1Yinu Wang (NU: Northwestern University)H-Index: 4
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 13 authors...
Defining traits of platinum tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum tolerant cells and tumors were identified by using in vitro and in vivo ovarian cancer (OC) models treated repetitively with carboplatin and validated in human specimens. Platinum-tolerant cells and tumors were found to be enriched in ALDH (+) cells, formed more spheroids, and expressed increased levels of stemness-related transcription factors compared to pare...
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