Xiaochuan Liu
University of California, Riverside
P70-S6 Kinase 1Messenger RNADrug resistancePhosphorylationShuttle vectorCell signalingMolecular biologyAdenylate kinaseEnzymeJanus kinase 3KinaseChemistryApoptosisAutophagyTerpenoidREV1Translational efficiencyPyrophosphatePhosphateTamoxifenMelanomaGuanineMetastasisHexokinaseDeoxyguanosineProtein prenylationProteomic ProfilingMethylationStable isotope labeling by amino acids in cell cultureCancer researchp38 mitogen-activated protein kinasesKinomeDNABiochemistrySignal transductionTransversionDNA replicationReprogrammingCell culturePolymeraseEstrogen receptorHDAC1PI3K/AKT/mTOR pathwayBiologyUntranslated regionCell biologyCancer cell
6Publications
3H-index
23Citations
Publications 6
Newest
#1Xiaochuan LiuH-Index: 3
#2Jun YuanH-Index: 4
Last. Yinsheng WangH-Index: 61
view all 7 authors...
Tamoxifen has been used for years for treating estrogen receptor-positive breast cancer; drug resistance, however, constitutes one of the main challenges for this therapy. We found that the protein expression level of ATF3 is significantly higher in tamoxifen-resistant (TamR) MCF-7 cells than the corresponding parental cancer cells. In addition, ATF3 protein expression is positively correlated with the resistance of TamR MCF-7 cells to 4-hydroxytamoxifen (4-OHT). Mechanistically, elevated ATF3 p...
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#1Xiaochuan Liu (UCR: University of California, Riverside)H-Index: 3
#2Gwendolyn Gonzalez (UCR: University of California, Riverside)H-Index: 6
Last. Yinsheng Wang (UCR: University of California, Riverside)H-Index: 61
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N6-methyladenosine (m6A) is the most abundant internal modification in mRNA and this methylation constitutes an important regulatory mechanism for the stability and translational efficiency of mRNA. In this study, we found that the protein levels of adenylate kinase 4 (AK4) and m6A writer METTL3 are significantly higher in tamoxifen-resistant (TamR) MCF-7 cells than in parental cells. The TamR MCF-7 cells also exhibit increased methylation at multiple m6A consensus motif sites in the 5′ untransl...
9 CitationsSource
#1Rong Cai (UCR: University of California, Riverside)H-Index: 1
#2Xuejiao Dong (UCR: University of California, Riverside)H-Index: 1
Last. Yinsheng Wang (UCR: University of California, Riverside)H-Index: 61
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Isoprenoid pyrophosphates are involved in protein prenylation and assume regulatory roles in cells; however, little is known about the cellular proteins that can interact with isoprenoid pyrophosph...
1 CitationsSource
#1Weili Miao (UCR: University of California, Riverside)H-Index: 9
#2Lin Li (UCR: University of California, Riverside)H-Index: 11
Last. Yinsheng Wang (UCR: University of California, Riverside)H-Index: 61
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Kinases are involved in numerous critical cell signaling processes, and dysregulation in kinase signaling is implicated in many types of human cancers. In this study, we applied a parallel-reaction monitoring (PRM)-based targeted proteomic method to assess kinome reprogramming during melanoma metastasis in three pairs of matched primary/metastatic human melanoma cell lines. Around 300 kinases were detected in each pair of cell lines, and the results showed that Janus kinase 3 (JAK3) was with red...
3 CitationsSource
#1Xiaochuan Liu (UCR: University of California, Riverside)H-Index: 3
#2Weili Miao (UCR: University of California, Riverside)H-Index: 9
Last. Yinsheng Wang (UCR: University of California, Riverside)H-Index: 61
view all 6 authors...
: Tamoxifen has been clinically used in treating estrogen receptor (ER)-positive breast cancer for over 30 years. The most challenging aspect associated with tamoxifen therapy is the development of resistance in initially responsive breast tumors. We applied a parallel-reaction monitoring (PRM)-based quantitative proteomic method to examine the differential expression of kinase proteins in MCF-7 and the isogenic tamoxifen-resistant (TamR) cells. We were able to quantify the relative protein expr...
8 CitationsSource
#1Jun Wu (UCR: University of California, Riverside)H-Index: 4
#2Hua Du (UCR: University of California, Riverside)H-Index: 3
Last. Yinsheng Wang (UCR: University of California, Riverside)H-Index: 61
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Endogenous metabolites and exogenous chemicals can induce covalent modifications on DNA, producing DNA lesions. The N2 of guanine was shown to be a common alkylation site in DNA; however, not much is known about the influence of the size of the alkyl group in N2-alkyldG lesions on cellular DNA replication or how translesion synthesis (TLS) polymerases modulate DNA replication past these lesions in human cells. To answer these questions, we employ a robust shuttle vector method to investigate the...
4 CitationsSource