Bilal B. Hafeez
University of Texas at Austin
Publications 5
#1Andrew E. Massey (NIH: National Institutes of Health)H-Index: 5
#2Shabnam MalikH-Index: 8
Last. Bilal B. Hafeez (University of Texas at Austin)H-Index: 2
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Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implication...
#1Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
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Pancreatic cancer (PanCa) is a highly lethal disease with a poor 5 year survival rate, less than 7%. It has a dismal prognosis, and more than 50% of cases are detected at an advanced and metastatic stage. Gemcitabine (GEM) is a gold standard chemotherapy used for PanCa treatment. However, GEM-acquired resistance in cancer cells is considered as a major setback for its continued clinical implementation. This phenomenon is evidently linked to de novo lipid synthesis. PanCa cells rely on de novo li...
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 24
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 1
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 5
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Background: Cervical cancer (CxCa) ranks as the fourth most prevalent women-related cancer worldwide. Therefore, there is a crucial need to develop newer treatment modalities. Ormeloxifene (ORM) is a non-steroidal, selective estrogen receptor modulator (SERM) that is used as an oral contraceptive in humans. Recent investigations suggest that ORM exhibits potent anti-cancer activity against various types of cancers. Nanoparticulates offer targeted delivery of anti-cancer drugs with minimal toxici...
1 CitationsSource
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 24
#1Neeraj Chauhan (University of Texas at Austin)H-Index: 1
Last. Meena Jaggi (University of Texas at Austin)H-Index: 1
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Selective estrogen receptor modulator drug molecules of triphenylethylene family have gained considerable attention as anti-cancer agents. Despite recent advances in screening and development of HPV vaccines, cervical cancer remains one of the deadliest malignancies as advanced stage metastatic disease is mostly untreatable, thus warrants newer therapeutic strategies. Ormeloxifene (ORM) is a well-known SERM of triphenylethylene family that has been approved for human use, thus represents an idea...
2 CitationsSource
#1Bilal Bin HafeezH-Index: 29
#1Bilal B. HafeezH-Index: 2
Last. Subhash C. ChauhanH-Index: 5
view all 11 authors...