Biao Cheng
Third Military Medical University
Mural cellEndocrinologySurgeryClinical uses of mesenchymal stem cellsRegeneration (biology)ChemistryMesenchymal stem cellSympathetic trunkSympathetic nervous systemVaginal atrophyCurcuminSympathectomyPLGAVaginismusWound healingAngiogenesisParacrine CommunicationMedicineParacrine signallingNanofiber
10Publications
5H-index
114Citations
Publications 10
Newest
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Junfeiyang Yin (Southern Medical University)
Last. Wenhua Huang (Southern Medical University)H-Index: 2
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Vaginal atrophy caused by the aging process and perineal trauma has a negative impact on women. A new vaginal atrophy treatment is injection of materials into the vaginal wall, including platelet-rich plasma (PRP), autogenous fat graft (AFG), hyaluronic acid (HA), botulinum toxin (BTX), and collagen, but to date their efficacy has not been reviewed. Vaginal wall injection is available only for mild cases of vaginal atrophy or as an adjunct to vaginal surgery. PRP is used mainly to restore vagina...
Source
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu Liu (Third Military Medical University)H-Index: 3
Last. Biao Cheng (Third Military Medical University)H-Index: 5
view all 7 authors...
AbstractDiabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide–polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel mater...
10 CitationsSource
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu Liu (Third Military Medical University)H-Index: 3
Last. Biao ChengH-Index: 5
view all 6 authors...
BACKGROUND: The effect of lumbar sympathectomy for the treatment of lower limb ischemia remains a matter of controversy. METHODS: Sprague-Dawley rats were subjected to lumbar sympathectomy, after which Evans blue dye was injected into the hind plantar skin. Extravasation of dye was measured and compared with rats undergoing sham operation. Hind plantar skin was processed for HE staining, immunohistochemistry, and Western blot. RESULTS: In sympathectomized rats, blue stained areas in hind plantar...
4 CitationsSource
#1Rui Guo (JNU: Jinan University)H-Index: 19
#2Yong Lan (JNU: Jinan University)H-Index: 14
Last. Seeram Ramakrishna (JNU: Jinan University)H-Index: 5
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Burn infection is a serious problem that delays wound healing and leads to death. Curcumin (Cur) has been shown to exhibit antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic activity. However, its instability, extremely low aqueous solubility and bioavailability in physiological fluids may make it difficult to maintain local Cur concentrations above the minimum inhibitory concentration for burn infection treatment. The objective of this study was to construct complexes of Cur/gel...
36 CitationsSource
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yu Wan (Southern Medical University)H-Index: 1
Last. Biao ChengH-Index: 1
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Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported. In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline. Full-thickness wounds were established on the backs of mice. The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after in...
2 CitationsSource
#1Yunfei Mo (JNU: Jinan University)H-Index: 6
#2Rui Guo (JNU: Jinan University)H-Index: 19
Last. Yuanming Zhang (JNU: Jinan University)H-Index: 5
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In this study, we successfully fabricated a novel drug and plasmid DNA (pDNA) dual delivery system by electrospinning the dispersion composed of polyethyleneimine-carboxymethyl chitosan/pDNA-angiogenin (ANG) nanoparticles, curcumin (Cur), poly (D, L-lactic-co-glycolic acid) (PLGA), and cellulose nanocrystals (CNCs). In vitro release studies showed that the bioactivity of Cur and ANG was preserved in the nanofibers, and a sequential release pattern was achieved in which nearly 90% of the Cur was ...
30 CitationsSource
#1Zhifang Zheng (Southern Medical University)H-Index: 3
#2Yishu Liu (Third Military Medical University)H-Index: 3
Last. Biao Cheng (Third Military Medical University)H-Index: 5
view all 6 authors...
Local sympathetic denervation by surgical sympathectomy is used in the treatment of lower limb ulcers and ischemia, but the restoration of cutaneous sympathetic nerve functions is less clear. This study aims to explore the recovery of cutaneous sympathetic functions after bilateral L2-4 sympathectomy. The skin temperature of the left feet, using a point monitoring thermometer, increased intraoperatively after sympathectomy. The cytoplasm of sympathetic neurons contained tyrosine hydroxylase and ...
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#1Zhifang ZhengH-Index: 3
#2Yu WanH-Index: 1
Last. Biao ChengH-Index: 5
view all 7 authors...
BACKGROUND: Sympathetic denervation and impaired angiogenesis cause skin diseases. However, the relationship between the sympathetic nervous system and vascular cell turnover in normal skin remains unclear. OBJECTIVE: To determine the effects of sympathetic denervation on vascular cell turnover in normal skin. METHODS: Rats underwent bilateral L2-4 sympathetic trunk resection (sympathectomy group) or sham operation (control). Hindfoot plantar skin was analyzed 2 weeks and 3 months postoperativel...
1 CitationsSource
#1Liangli Pan (Southern Medical University)H-Index: 3
#2Jianbing TangH-Index: 1
Last. Biao ChengH-Index: 5
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Angiogenesis is essential for wound healing, and angiogenesis impairment can result in chronic ulcers. Studies have shown that the sympathetic nervous system has an important role in angiogenesis. In recent years, researchers have focused on the roles of sympathetic nerves in tumor angiogenesis. In fact, sympathetic nerves can affect angiogenesis in the wound healing of soft tissues, and may have a similar mechanism of action as that seen in tumorigenesis. Sympathetic nerves act primarily throug...
13 CitationsSource
#1Yan PengH-Index: 1
#2Min XuanH-Index: 3
Last. Biao ChengH-Index: 5
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The mesenchymal stem cell (MSC) supernatant is well known as a rich source of autologous cytokines and universally used for tissue regeneration in current clinical medicine. However, the limitation of conditioned medium used in open-wound repair compels the need to find a more sophisticated way to take advantage of the trophic factors of MSCs. We have now fabricated a three-dimensional membrane from freeze-dried bone marrow mesenchymal stem cells-conditioned medium (FBMSC-CM) using a simple free...
15 CitationsSource