A.D. van den Brand
Utrecht University
Dopamine receptorInternal medicineEndocrinologyGene expressionEndogenyChemistryIn vivoHormone receptorGREB1QuinpiroleProlactinUterusEndometriumEstrogen receptor bindingAryl hydrocarbon receptorSecretionCytochrome P450HormoneCell cultureEstrogen receptor
3Publications
2H-index
6Citations
Publications 3
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#1A.D. van den Brand (UU: Utrecht University)H-Index: 2
#2E. RubinsteinH-Index: 2
Last. Mbm van Duursen (VU: VU University Amsterdam)H-Index: 1
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Abstract Unopposed estrogenic action in the uterus can lead to the development of endometrial cancer in both humans and rats. Aryl hydrocarbon receptor (AHR) activation gives rise to anti-estrogenic actions and may consequently reduce the development of endometrial cancer. In this study, the anti-estrogenic potential of the AHR ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and DELAQ, a metabolite of the pharmaceutical laquinimod, was assessed in in primary human and rat endometrial epitheli...
1 CitationsSource
#1A.D. van den Brand (UU: Utrecht University)H-Index: 2
#2E. RubinsteinH-Index: 2
Last. M.B.M. van Duursen (VU: VU University Amsterdam)H-Index: 2
view all 5 authors...
Abstract Human and rat reproductive systems differ significantly with respect to hormonal cyclicity and endometrial cell behavior. However, species-differences in endometrial cell responses upon hormonal stimulation and exposure to potentially toxic compounds are poorly characterized. In this study, human and rat endometrial hormonal responses were assessed in vitro using a 3D co-culture model of primary human and rat endometrial cells. The models were exposed to the aryl hydrocarbon receptor (A...
4 CitationsSource
#1A.D. van den Brand (UU: Utrecht University)H-Index: 2
#2E. RubinsteinH-Index: 2
Last. M.B.M. van Duursen (VU: VU University Amsterdam)H-Index: 2
view all 4 authors...
Abstract Some environmental contaminants and pharmaceuticals increase the incidence of uterine tumors in toxicological studies with rats. These tumors can result from a hormonal imbalance due to rat-specific disrupted pituitary prolactin regulation, and are therefore of questionable relevance for humans. In this study we compared in vitro prolactin regulation in rat primary pituitary cells to that in pituitary cell lines, GH3 and RC-4BC. Moreover, we assessed the potential effects of aryl hydroc...
3 CitationsSource