Joan Wobig
Cardiac function curveInternal medicineSurgeryMagnetic resonance imagingCardiologyAdverse effectBleedUmbilical cordHeart failureVentricleStem-cell therapyHypoplastic left heart syndromeImplantable loop recorderTricuspid valveContext (language use)Surgical repairPhases of clinical researchPhysical examinationMedicine
2Publications
1H-index
21Citations
Publications 2
Newest
#1Holst Kimberly A (UR: University of Rochester)H-Index: 1
#2Joseph A. Dearani (UR: University of Rochester)H-Index: 95
Last. Karen Cavanaugh (Mayo Clinic)H-Index: 2
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Abstract Background The objective of this study is to assess the safety and early impact of intramyocardial delivery of autologous bone marrow-derived mononuclear cells (BM-MNC) at time of surgical Ebstein repair. Methods Patients with EA (ages 6 months to 30 years) scheduled to undergo repair of the TV were eligible to participate in this open label, non-randomized Phase I clinical trial. BM-MNC target dose was 1-3 million cells/kg. Ten patients have undergone surgical intervention and cell del...
1 CitationsSource
#1Harold M. Burkhart (OU: University of Oklahoma)H-Index: 53
#2Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 10
Last. Joan WobigH-Index: 1
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Abstract Objectives Staged surgical palliation for hypoplastic left heart syndrome results in an increased workload on the right ventricle serving as the systemic ventricle. Concerns for cardiac dysfunction and long-term heart failure have generated interest in first-in-infant, cell-based therapies as an additional surgical treatment modality. Methods A phase 1 clinical trial was conducted to evaluate the safety and feasibility of direct intramyocardial injection of autologous umbilical cord blo...
20 CitationsSource