Ke Zhou
Zhejiang University
GeneProdrugFibroblast activation protein, alphaRisk assessmentInternal medicineGene expressionKEGGProinflammatory cytokineOrgan transplantationKinaseChemistryIn vitroImmunohistochemistryT cellVascular endothelial growth factorHepatocellular carcinomaHeart transplantationSTAT3PEGylationRenal replacement therapyLiver transplantationImmunosuppressionFibroblastAcute kidney injuryFibrosisTacrolimusMycophenolateTropismIncidence (epidemiology)Cancer researchCarcinogenesisMedicineCohortTranscription factorBiologyImmune systemGastroenterologyPharmacology
Publications 5
#1Ke ZhouH-Index: 1
#2Xiaona ChenH-Index: 7
Last. Penghong SongH-Index: 17
view all 14 authors...
Organ transplantation has become a mainstay of therapy for patients with end-stage organ diseases. However, long-term administration of immunosuppressive agents, a scheme for improving the survival of transplant recipients, has been compromised by severe side effects and posttransplantation complications. Therapeutic delivery targeting immune organs has the potential to address these unmet medical issues. Here, through screening of a small panel of mammalian target of rapamycin complex kinase in...
#1Zhentao YangH-Index: 2
#2Liang ZhangH-Index: 3
Last. Haiyang XieH-Index: 57
view all 13 authors...
Hepatocellular carcinoma (HCC) is one of the most aggressive tumours with marked fibrosis. Mycophenolate mofetil (MMF) was well-established to have antitumour and anti-fibrotic properties. To overcome the poor bioavailability of MMF, this study constructed two MMF nanosystems, MMF-LA@DSPE-PEG and MMF-LA@PEG-PLA, by covalently conjugating linoleic acid (LA) to MMF and then loading the conjugate into polymer materials, PEG5k -PLA8k and DSPE- PEG2k , respectively. Hepatocellular carcinoma cell line...
#1Haiyang Xie (ZJU: Zhejiang University)H-Index: 57
#2Hai Zhu (ZJU: Zhejiang University)H-Index: 3
Last. Hangxiang Wang (ZJU: Zhejiang University)H-Index: 25
view all 11 authors...
Organ transplantation remains the gold standard therapeutic option for patients with end-stage organ failure. However, there have been few improvements in the management of post-transplant immunosuppression. As the long-term use of immunosuppressive agents (ISAs) may result in off-target systemic toxicity and complications, minimizing the ISA dosage while preserving the pharmacological efficacy could be a promising solution to address these challenges. Here, we present the design and application...
8 CitationsSource
#1Hai Zhu (ZJU: Zhejiang University)H-Index: 3
#2Zhentao Yang (ZJU: Zhejiang University)H-Index: 2
Last. Shusen Zheng (ZJU: Zhejiang University)H-Index: 64
view all 10 authors...
Development of hepatocellular carcinoma (HCC) is a dynamic process that includes a spectrum ranging from precancerous exposure to carcinogenesis and metastasis stages. In this process, numerous dysregulated genes resulted in aberrant activation or inhibition of signaling pathways. Herein, time-series gene expression profiles of dimethylnitrosamine (DEN)-induced mice with HCC covering different stages are provided. Gene expression patterns of liver tissues were detected at different time interval...
#1Haiyang XieH-Index: 57
#2Liang Zhang (ZJU: Zhejiang University)H-Index: 3
Last. Shusen ZhengH-Index: 64
view all 14 authors...
BACKGROUND: Predicting the development of early allograft dysfunction (EAD) following liver transplantation (LT) remains challenging for transplant clinicians. The objectives of this study are to investigate the potential relationship between the protein profiles of pretransplant grafts and the onset of EAD, and then combine with clinical parameters to construct a mathematically predictive model. METHODS: Clinical data of 121 LT procedures from donation after circulatory death at the authors' ce...
1 CitationsSource