Tomoka Ikeda
Okayama University
Somatic hypermutationImmunoglobulin class switchingPathologyMucocutaneous zoneAntibodyDermatologyLymphatic systemImmunologyImmunohistochemistryPathologicalVirusActivation-induced (cytidine) deaminaseChemotherapyInflammationCytidine deaminaseB cellDiffuse large B-cell lymphomaImmunosenescenceHydroxycarbamideLymphomaMalignancyImmunosuppressionWaldenstrom macroglobulinemiaMethotrexateLesionAggressive lymphomaEBV PositiveLymphoplasmacytic LymphomaEpstein-Barr Virus-Positive Mucocutaneous UlcerMucocutaneous ulcersDisease progressionGene rearrangementCancer researchHistologyMedicineIL-2 receptorBiologyImmune systemGerminal center
5Publications
2H-index
25Citations
Publications 5
Newest
#1Hiroki Kobayashi (Okayama University)H-Index: 1
#2Noboru Asada (Okayama University)H-Index: 15
Last. Yoshinobu Maeda (Okayama University)H-Index: 29
view all 17 authors...
Waldenstrom macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare indolent B-cell neoplasm, and a gain-of-function mutation in the myeloid differentiation primary response 88 (MYD88), L265P, is a commonly recurring mutation in patients with WM/LPL. Histological transformation of WM/LPL to an aggressive lymphoma such as diffuse large B-cell lymphoma (DLBCL) is rare, and transformed DLBCL has a worse prognosis than de novo DLBCL, partly because transformed DLBCL is mostly classified as...
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Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been ...
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#1Tomoka Ikeda (Okayama University)H-Index: 2
#2Yuka Gion (RMIT: RMIT University)H-Index: 13
Last. Yasuharu Sato (Okayama University)H-Index: 32
view all 6 authors...
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) was first described as a lymphoproliferative disorder in 2010. EBVMCU is a unifocal mucosal or cutaneous ulcer that often occurs after local trauma in patients with immunosuppression; the patients generally have a good prognosis. It is histologically characterized by proliferating EBV-positive atypical B cells accompanied by ulcers. On the basis of conventional pathologic criteria, EBVMCU may be misdiagnosed as EBV-positive diffuse l...
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#1Tomoka Ikeda (Okayama University)H-Index: 2
#2Yuka Gion (RMIT: RMIT University)H-Index: 13
Last. Yasuharu Sato (RMIT: RMIT University)H-Index: 32
view all 8 authors...
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a unifocal mucosal or cutaneous ulcer that is histologically characterized by proliferating EBV-positive atypical B cells. While EBVMCU demonstrates a histology similar to that of EBV-positive diffuse large B-cell lymphoma (DLBCL), their clinical behavior differs. Thus, characterizing distinguishing features of EBVMCU and EBV-positive DLBCL is critical. To identify unique characteristics between EBVMCU and lymphoma, we analyzed th...
4 CitationsSource
Epstein-Barr virus (EBV)-positive mucocutaneous ulcers (EBVMCUs) were first described as a lymphoproliferative disorder in 2010. Clinically, EBVMCUs are shallow, sharply circumscribed, unifocal mucosal or cutaneous ulcers that occur in immunosuppressed patients, including those with advanced age-associated immunosenescence, iatrogenic immunosuppression, primary immune disorders, and HIV/AIDS-associated immune deficiencies. In general, patients exhibit indolent disease progression and spontaneous...
16 CitationsSource