Ilangovan Ramachandran
University of Madras
CancerInternal medicineDownregulation and upregulationSidestream smokeEndocrinologyWnt signaling pathwayDNA damagemicroRNAMolecular biologyChemistryMitotic catastropheApoptosisMetastasisWIF1PopulationCell cycleEpigeneticsCancer researchColorectal cancerViability assayDNACancer stem cellCell growthMedicineBiologyCell biologyCancer cellPharmacology
49Publications
11H-index
715Citations
Publications 47
Newest
#1Mohan Damodaran (SRU: Sri Ramachandra University)H-Index: 1
#2Mohanapriya Chinambedu Dandapani (SRU: Sri Ramachandra University)
Last. Vettriselvi Venkatesan (SRU: Sri Ramachandra University)H-Index: 7
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Prostate cancer is the leading cause of death among men worldwide. Deregulation of microRNAs has been reported in many cancers. Expression of microRNAs miR-20a-5p, miR-21-5p, miR-100-5p, miR-125a-5p and miR-146a-5p in tissue blocks of histologically confirmed prostate cancer patients compared with BPH patients, to identify potential microRNA biomarker for prostate cancer. MicroRNA was isolated and expression was quantified by qRT-PCR using Taqman Advanced microRNA assay kits. The interactions be...
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#1Ilangovan Ramachandran (University of Madras)H-Index: 11
#2Sivakumar Ramadoss (UCLA: University of California, Los Angeles)H-Index: 10
Last. Gautam Chaudhuri (UCLA: University of California, Los Angeles)H-Index: 55
view all 6 authors...
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#1Shabana Thabassum Mohammed Rafi (University of Madras)
#2Yuvaraj Sambandam (NU: Northwestern University)H-Index: 1
Last. R. Ileng Kumaran (Farmingdale State College)H-Index: 1
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Abstract Skeletal muscle tissue-resident muscle stem cells, also called satellite cells, can undergo self-renewal and differentiation via adult myogenesis to generate muscle lineage through adult life. Satellite cells remain dormant in the quiescent state until the muscle suffers an injury. Upon damage to the muscle, the dormant satellite cells are activated, resulting in myogenesis mediated by its microenvironment. There is a progressive decline in the regenerative capacity of the muscles due t...
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#1Sridhar MuthusamiH-Index: 9
#2Ilangovan Ramachandran (University of Madras)H-Index: 11
Last. R. Ileng Kumaran (Farmingdale State College)H-Index: 1
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The development of colorectal cancer (CRC) is a multi-stage process. The inflammation of the colon as in inflammatory bowel disease (IBD) such as ulcerative colitis (UC) or Crohn's disease (CD) is often regarded as the initial trigger for the development of CRC. Many cytokines such as tumor necrosis factor alpha (TNF-α) and several interleukins (ILs) are known to exert proinflammatory actions, and inflammation initiates or promotes tumorigenesis of various cancers, including CRC through differen...
1 CitationsSource
#1Manju Mohan (University of Madras)H-Index: 1
#2Sridhar Muthusami (Karpagam University)H-Index: 9
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
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Abstract Cellular senescence is a hallmark of aging that is characterized by irreversible cell cycle arrest in response to various stress stimuli. It is a normal physiological event, which plays essential role in development, prevention of cancer, wound healing process, etc. Nevertheless, accumulation of senescent cells is the trigger and forms the basis of aging of a tissue/organ and, thus, the organismal aging. During aging, cells display a senescence-associated secretory phenotype (SASP) that...
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Background To understand the mechanism underlying tamoxifen-induced multidrug resistance (MDR) and stem-like phenotypes in breast cancer cells, we treated the MCF-7 cells with 4-hydroxy-tamoxifen (TAM) for 6 months continuously and established MCF-7 tamoxifen resistance (TR) phenotypes. Methods In the present study, the following methods were used: cell viability assay, colony formation, cell cycle analysis, ALDEFLUOR assay, mammosphere formation assay, chromatin immunoprecipitation (ChIP) assay...
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#2Sivakumar RamadossH-Index: 10
Last. Gautam ChaudhuriH-Index: 55
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Introduction: Ovarian cancer is one of the most common malignancies among women that causes severe mortality in USA and globally. Despite advances in cancer treatments in the last few decades, there is no substantial improvement in the survival rates of patients with advanced ovarian cancers. This is mainly attributed to drug resistance and tumor recurrence. Most patients develop resistance to platinum compounds, which are often used as the first-line therapy. Several studies have shown that ald...
1 CitationsSource
#1Thangavel Muthusamy (University College West)H-Index: 1
#2L. Roshini YadavH-Index: 1
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
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#1Ilangovan Ramachandran (University of Madras)H-Index: 11
#2Sivakumar Ramadoss (UCLA: University of California, Los Angeles)H-Index: 10
Last. Gautam Chaudhuri (UCLA: University of California, Los Angeles)H-Index: 55
view all 5 authors...
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#1Abhaya KrishnanH-Index: 2
#2Sridhar MuthusamiH-Index: 9
Last. Ilangovan Ramachandran (University of Madras)H-Index: 11
view all 6 authors...
Background and Objectives: Polycystic ovary syndrome (PCOS) is one of the most prevalent disorders among women of reproductive age. It is considered as a pro-inflammatory state with chronic low-grade inflammation, one of the key factors contributing to the pathogenesis of this disorder. Polycystic ovary is a well-established criterion for PCOS. The present investigation aimed at finding the role of hyperandrogenism, the most important feature of PCOS, in the development of this inflammatory stat...
3 CitationsSource