Kamalika Samanta
University of Tennessee Health Science Center
OffspringDrug resistanceCancerInternal medicineGene deliveryOncologyAbsorption (skin)NanomedicineAntibodyEnzooticBioavailabilityNanocarriersLiposomeChemistryIngestionAdverse effectImmunologyMicrovesiclesVaccinationAtezolizumabChemotherapyProteaseCombination therapyMucusLyme diseaseEnteric coatingPancaMatrigelRodentColostrumBorrelia burgdorferiDrug deliveryOlaparibTriple-negative breast cancerPancreatic cancerGemcitabineKRASExosomeAvailable drugsSystemic toxicityEffective managementProteolytic enzymesCancer researchBreast cancerViability assayTransfectionCell growthMedicineBiologyCancer cellPharmacology
7Publications
2H-index
23Citations
Publications 7
Newest
#1Kathryn Phillip (UTHSC: University of Tennessee Health Science Center)
#2Nisha Nair (UTHSC: University of Tennessee Health Science Center)H-Index: 3
Last. Maria Gomes-Solecki (UTHSC: University of Tennessee Health Science Center)H-Index: 18
view all 7 authors...
Abstract null null Lyme Disease presents unique challenges for public health. Transfer of protective antibodies between mothers and offspring should occur after vaccination of mice. We present new evidence for maternal transfer of oral vaccine induced neutralizing anti-OspA IgG antibodies to mouse pups mainly through ingestion of colostrum. We found a strong statistical correlation of antibody transfer between mothers that produced the most robust IgG response to OspA and their respective pups. ...
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#1Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
#2Upasana Ghosh (RU: Rutgers University)
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
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The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeuti...
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#1Kathryn O'Connell (UTHSC: University of Tennessee Health Science Center)H-Index: 1
#2Nisha Nair (UTHSC: University of Tennessee Health Science Center)H-Index: 3
Last. Maria Gomes-Solecki (UTHSC: University of Tennessee Health Science Center)H-Index: 18
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Lyme Disease presents unique challenges for public health efforts. We hypothesized that transfer of protective antibodies between mothers and offspring should occur after oral vaccination of C3H-HeN mice with E. coli overexpressing OspA. We present new evidence for maternal transfer of vaccine induced neutralizing anti-OspA IgG antibodies to mouse pups through ingestion of colostrum. Protective levels of OspA antibodies in pups were present from 2-5 weeks after birth and they persisted in some m...
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#1Nirnoy Dan (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Kamalika Samanta (UTHSC: University of Tennessee Health Science Center)H-Index: 2
Last. Hassan Almoazen (UTHSC: University of Tennessee Health Science Center)H-Index: 8
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While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell barriers in the gastrointestinal (GI) tract that can block access of larger molecules including Therapeutic protein or peptide-based drugs (TPPs), resulting in reduced bioavailability. This review desc...
3 CitationsSource
#1Kamalika Samanta (UTHSC: University of Tennessee Health Science Center)H-Index: 2
#2Saini Setua (UTHSC: University of Tennessee Health Science Center)H-Index: 7
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 5
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Pancreatic cancer is one of the deadliest causes of cancer-related death in the United States, with a 5-year overall survival rate of 6 to 8%. These statistics suggest that immediate medical attention is needed. Gemcitabine (GEM) is the gold standard first-line single chemotherapy agent for pancreatic cancer but, after a few months, cells develop chemoresistance. Multiple clinical and experimental investigations have demonstrated that a combination or co-administration of other drugs as chemothe...
21 CitationsSource
#1Kamalika SamantaH-Index: 2
#2Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
Last. Subhash Chandra Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 1
view all 8 authors...
Background-Pancreatic cancer (PanCa) is the third deadliest cancer in United States with a poor survival rate. Despite extensive research efforts, there is no substantial progress in cancer therapeutics due to barrier against intracellular drug delivery. Our group has previously identified that microRNA-145 (miR-145) is downregulated in PanCa, the restoration of which inhibits tumor growth and enhances gemcitabine sensitivity. However, lack of an effective tumor-specific delivery system remains ...
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#1Nirnoy Dan (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 9 authors...
Background: Although, surgical resection and chemotherapy are the gold standard for treating pancreatic cancer (PanCa), poor patient survival remains the problem. Despite being one of the most common oncogenes in human cancer, to date, no success has been achieved to inhibit KRAS. Targeting KRAS has been shown to synergize anti-cancer activity of gemcitabine in pancreatic cancer. Herein, we have developed a supermagnetic iron oxide (SP) nanoparticles for the sustained delivery of KRAS siRNA to t...
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