Yusuke Goto
University of California, San Diego
PTK2HRASCopy-number variationCancerCannabinoid receptorCellular differentiationCellTranscriptomeGene knockdownChemistrySmall hairpin RNAApoptosisSmall interfering RNAStimulationTumor microenvironmentHead and neck cancerTipifarnibHead and neck squamous-cell carcinomaCarcinomaTyrosine phosphorylationPTENImmunotherapyAndrogenAnimal modelTumor suppressor geneFarnesyltransferaseBlockadeCetuximabNivolumabPembrolizumabProstate cancerMetforminImmune checkpointCannabinoidOncogeneSquamous DifferentiationImmune infiltrationAnti ctla 4Poor prognosisMuscarinic acetylcholine receptorCancer researchPrenylationAndrogen receptorCell growthSignal transductionMedicineBiomarker (medicine)Protein kinase BCell culturePI3K/AKT/mTOR pathwayBiologyImmune systemCancer cell
9Publications
5H-index
72Citations
Publications 8
Newest
#1Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
#2Yusuke Goto (UCSD: University of California, San Diego)H-Index: 5
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 15 authors...
Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but <20% of patients achieve durable responses. Persistent activation of the PI3K/AKT/mTOR signaling circuitry represents a key oncogenic driver in HNSCC; however, the potential immunosuppressive effects of PI3K/AKT/mTOR inhibitors may limit the benefit of their combination with ICB. Here we employ an unbiased kinome-wide siRNA screen to reveal that HER3, is essential for the prol...
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#1Mara Gilardi (UCSD: University of California, San Diego)H-Index: 11
#2Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
Last. Francis BurrowsH-Index: 29
view all 14 authors...
Tipifarnib is a potent and highly selective inhibitor of farnesyltransferase (FT). FT catalyzes the post-translational attachment of farnesyl groups to signaling proteins that are required for localization to cell membranes. Although all RAS isoforms are FT substrates, only HRAS is exclusively dependent upon farnesylation, raising the possibility that HRAS mutant tumors might be susceptible to tipifarnib-mediated inhibition of FT. Here, we report the characterization of tipifarnib activity in a ...
8 CitationsSource
#1Chao Liu (UCSD: University of California, San Diego)H-Index: 19
#1Chao Liu (UCSD: University of California, San Diego)H-Index: 6
Last. Joseph A. Califano (UCSD: University of California, San Diego)H-Index: 89
view all 19 authors...
Purpose: Human papilloma virus (HPV) related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in parallel with increased marijuana use in the United States. Our study is designed to define the interaction between cannabinoids and HPV positive HNSCC. Experimental Design: The expression of cannabinoid receptors CNR1 and CNR2 was analyzed using The Cancer Genome Atlas (TCGA) HNSCC data. We used agonists, antagonists, siRNAs or shRNA based m...
6 CitationsSource
#1Hiroki Izumi (UCSD: University of California, San Diego)H-Index: 2
#2Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 10 authors...
Cetuximab, a monoclonal antibody targeting EGFR, is a standard of care for the treatment for locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC). However, despite overexpression of EGFR in over 90% of HNSCC lesions, most HNSCC patients fail to respond to cetuximab treatment. In addition, there are no available biomarkers to predict sensitivity or resistance to cetuximab in the clinic. Here, we sought to advance precision medicine approaches for HNSCC by identifying PI3K-...
3 CitationsSource
#1Yusuke Goto (UCSD: University of California, San Diego)H-Index: 5
#2Toshinori Ando (UCSD: University of California, San Diego)H-Index: 9
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 9 authors...
Prostate cancer (PCa) innervation contributes to the progression of PCa. However, the precise impact of innervation on PCa cells is still poorly understood. By focusing on muscarinic receptors, which are activated by the nerve-derived neurotransmitter acetylcholine, we show that muscarinic receptors 1 and 3 (m1 and m3) are highly expressed in PCa clinical specimens compared with all other cancer types, and that amplification or gain of their corresponding encoding genes (CHRM1 and CHRM3, respect...
8 CitationsSource
#1Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
#2Victoria Wu (UCSD: University of California, San Diego)H-Index: 9
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 19 authors...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately mimic the complexity of the HNSCC mutational landscape and tumor immune environm...
23 CitationsSource
#1Xingyu Wu (Sichuan University)H-Index: 5
#2Huwate Yeerna (UCSD: University of California, San Diego)H-Index: 11
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 13 authors...
Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented the stratification of patient populations who are most likely to benefit from metformin treatment. Here, we explored whether metformin acts directly on HNSCC cells to inhibit aberrant cell growth. To investigate the tumor cell autonomous effects of me...
11 CitationsSource
#1Zhiyong Wang (UCSD: University of California, San Diego)H-Index: 24
#2Victoria Wu (UCSD: University of California, San Diego)H-Index: 9
Last. J. Silvio Gutkind (UCSD: University of California, San Diego)H-Index: 119
view all 18 authors...
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately reflect the complexity of the HNSCC mutational landscape and tumor immune enviro...
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