Lei Xu
Shenyang Pharmaceutical University
ExcretionCytotoxicityPharmacodynamicsPharmacokineticsSleep in non-human animalsCancerSapogeninMolecular biologyCytotoxic T cellHigh-performance liquid chromatographyBioavailabilityChemistryCytoplasmApoptosisMetabolic pathwayIn vivoWestern blotGinsenosidePentobarbitalOral administrationHeLaMetaboliteSalicylic acidSaponinGinsengLinaloolDammaraneMTT assayHypnoticInsomniaPanax notoginsengMitochondrionNotoginsenoside R1Cytochrome cCell cycleFt icr msExtraction methodsChromatographyExtraction (chemistry)Reactive oxygen speciesBiochemistryAcupunctureADMESelected reaction monitoringMedicineProtein precipitationIntracellularQuantitative analysis (chemistry)Cancer cellPharmacology
7Publications
3H-index
11Citations
Publications 5
Newest
#1Shengnan Xiao (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Wang Xude (DUT: Dalian University of Technology)
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract In this study, piperazine groups were introduced into ginsenoside to enhance its ability to induce Reactive Oxygen Species (ROS) production and apoptosis in cancer cells. In total, 27 ginsenoside piperazine derivatives were synthesized and tested for their anti-proliferative activity in cancer cell lines by MTT assay. The results showed that compounds 4a, 4g, 4f, 4i, 5g, 5i, 6a, 6g, 6f and 6i had significant inhibitory effects on cancer cell growth. Compound 6g showed the strongest anti...
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#1Lei Xu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xiaofei Li (SPU: Shenyang Pharmaceutical University)
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 7 authors...
The Shenque acupoint is located in the umbilicus of the human body. In the human body meridians, the Shenque acupoint can regulate body functions. The Shenque acupoint was one of the important acupuncture acupoints for the treatment of insomnia. However, the effect of linalool applied at the Shenque acupoint to improve sleep was unknown. This study explored the hypnotic and sedative effects of the main component of lavender, linalool, on the Shenque acupoint of mice and rats. The effects on the ...
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#1Lei Xu (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Jing Xu (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 9 authors...
In this paper, we used the flash extraction method (FEM) to extract ginsenosides from mountain cultivated ginseng (MCG), optimized the FEM process by response surface methodology (RSM), and separated 23 kinds of ginsenosides from MCG, including rare ginsenoside Rg3, 20(R/S)-Rg2, Rk3, 20(S)-Rh2, 20(R)-Rh1, F1 and Rg6. Among them, notoginsenoside R1 was isolated from MCG for the first time. Additionally, we established an HPLC-FT-ICR-MS method to accurately identify 20 ginsenosides in MCG, and qua...
1 CitationsSource
#1Shengnan Xiao (SPU: Shenyang Pharmaceutical University)H-Index: 2
#2Xude Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 ± 0.54 μM, which was nearly 15 times higher than the activity of PD. Further st...
1 CitationsSource
#1Meng Ding (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Xude Wang (SPU: Shenyang Pharmaceutical University)H-Index: 5
Last. Yuqing Zhao (SPU: Shenyang Pharmaceutical University)H-Index: 16
view all 10 authors...
Abstract 20(R)-25-methoxyl-dammarane-3 β ,12 β ,20-triol (AD-1, CN Patent: 201010107476.7) is a novel derivative of dammarane-type ginsenoside. AD-1 has been shown to inhibit cancer cell proliferation without significant host toxicity in vivo , and has excellent development potential as a new anti-cancer agent. This study was designed systematically to explore the metabolic pathway of ginseng sapogenins. The metabolism of drugs in the body is a complex biotransformation process where drugs are s...
4 CitationsSource