L. Kosse
Radboud University Nijmegen
Internal medicineIntensive care medicineProspective cohort studyExact testMedDRAEtanerceptSafety monitoringResponse rate (survey)DiseaseImmune-mediated inflammatory diseasesPharmacistDrugAdalimumabAdverse drug reactionIndependent researchDrug reactionMedical informationRheumatic diseaseFamily medicineClinical trialPharmacovigilanceMedicineCohort
Publications 13
#1L. KosseH-Index: 2
#2Naomi T. JessurunH-Index: 5
Last. Michael T. Nurmohamed (VUmc: VU University Medical Center)H-Index: 63
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OBJECTIVES: Assessment of the quality of patient-reported medical information in the Dutch Biologic Monitor and evaluation of the representativeness of the sampled participants. METHODS: Consecutive adult patients using a biologic DMARD (bDMARD) for an immune-mediated inflammatory disease were included in eight Dutch centres. For this substudy, data of 550 patients with inflammatory rheumatic diseases were used. Patient-reported bDMARD prescription, indication and combination therapy were verifi...
5 CitationsSource
Background: To gain knowledge on the prevalence, course and treatment of adverse drug reactions (ADRs) attributed to biological DMARDs (bDMARDs) and the experienced impact of ADRs on patients, an ADR-focused online questionnaire system was developed by Netherlands Pharmacovigilance Centre Lareb (Dutch Biologic Monitor). 898 consecutive patients of eight centers who used a bDMARD indicated for an inflammatory rheumatic disease were followed between 1 January 2017 and 31 December 2018. Objectives:...
#1Theun de Groot (Radboud University Nijmegen)H-Index: 15
#2Lars Damen (Radboud University Nijmegen)H-Index: 2
Last. Peter M. T. Deen (Radboud University Nijmegen)H-Index: 62
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Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chronic GSK3 inhibition in diabetic nephropathy is not known. We tested the effect of lithium, the only clinical GSK3 inhibitor, on the development of diabetes mellitus and kidney injury in a mouse model...
5 CitationsSource