Sandra Fischer
University of Toronto
CancerInternal medicineRadiologySurgeryPathologyMagnetic resonance imagingOncologyTranscriptomeRetrospective cohort studyBiopsyChemotherapyCirrhosisLiver biopsyHepatocellular carcinomaFatty liverDiseaseLiver transplantationPancreatic cancerTransplantationCancer researchMedicineBiologyGastroenterology
Publications 114
#1Michael J AllenH-Index: 2
#2Amy Zhang (OICR: Ontario Institute for Cancer Research)H-Index: 7
Last. Julie M. Wilson (OICR: Ontario Institute for Cancer Research)H-Index: 12
view all 18 authors...
Aims null The majority of pancreatic ductal adenocarcinomas (PDACs) harbour oncogenic mutations in KRAS with variants in TP53, CDKN2A and SMAD4 also prevalent. The presence of oncogenic fusions including NTRK fusions are rare but important to identify. Here we ascertain the prevalence of NTRK fusions and document their genomic characteristics in a large series of PDAC. null Methods null Whole genome sequencing and RNAseq were performed on a series of patients with resected or locally advanced/me...
#1Katherine J. P. Schwenger (UHN: University Health Network)H-Index: 2
#2Alexander Kiu (UHN: University Health Network)
Last. Johane P. Allard (UHN: University Health Network)H-Index: 52
view all 6 authors...
Abstract null null Objective null Non-alcoholic fatty liver disease is a leading cause of liver disease worldwide and includes nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis. Since NASH is associated with obesity severity, routine evaluation of obesity/body fat in clinical settings may help detect patients at risk. This study aims to determine if assessing body fat by bioelectrical impedance analysis (BIA) is superior to body mass index (BMI) and waist circumference (WC) in...
#1Kai Duan (UHN: University Health Network)
#2Gun-Ho Jang (OICR: Ontario Institute for Cancer Research)H-Index: 5
Last. Sandra Fischer (UHN: University Health Network)H-Index: 25
view all 9 authors...
Combination chemotherapy, either modified FOLFIRINOX (mFFX) or gemcitabine–nabpaclitaxel, are used in the treatment of most patients with advanced pancreatic ductal adenocarcinoma (PDAC), yet robust biomarkers of outcome are currently lacking to guide regimen selection. Here, we tested GATA6 immunohistochemistry (IHC) as a putative biomarker in advanced PDAC. GATA6 is a transcription factor in normal pancreas development. Two pathologists, blinded to clinical and molecular data, independently as...
#1Kristel Leung (U of T: University of Toronto)H-Index: 4
#2Maya Deeb (U of T: University of Toronto)H-Index: 4
Last. Aliya Gulamhusein (UHN: University Health Network)H-Index: 13
view all 4 authors...
Patients with primary sclerosing cholangitis (PSC) constitute 5 to 15% of patients listed for liver transplantation worldwide. Although post-transplant outcomes are favorable, recurrent PSC (rPSC) occurs in an important subset of patients, with higher prevalence rates reported with increasing time from transplant. Given its association with poor graft outcomes and risk of retransplant, effort has been made to understand rPSC, its pathophysiology, and risk factors. This review covers these facets...
#1Fernanda de Quadros Onófrio (UHN: University Health Network)H-Index: 5
#2Evon Neong (UHN: University Health Network)H-Index: 1
Last. Nazia Selzner (UHN: University Health Network)H-Index: 32
view all 12 authors...
Background and Aims A 40% risk of disease recurrence post-liver transplantation (LT) for autoimmune hepatitis (AIH) has been previously reported. Risk factors for recurrence and its impact on long-term patient outcome are poorly defined. We aimed to assess prevalence, time to disease recurrence, as well as patient and graft survival in patients with recurrent AIH (rAIH) versus those without recurrence. Methods Single-center retrospective study of adult recipients who underwent LT for AIH between...
#1Andrzej Chruscinski (UHN: University Health Network)H-Index: 16
#2Stephen JuvetH-Index: 15
Last. Harold AtkinsH-Index: 1
view all 40 authors...
BACKGROUND Primary sclerosing cholangitis (PSC) is an indication for liver transplantation, but recurrence after liver transplantation is associated with poor outcomes often requiring repeat transplantation. We investigated whether autologous hematopoietic stem cell transplantation (aHSCT) could be used to stop progression of recurrent PSC and promote operational tolerance. METHODS Twelve patients with recurrent PSC were fully evaluated and 5 were selected for aHSCT. Autologous hematopoietic ste...
#8Yifan Wang (MUHC: McGill University Health Centre)H-Index: 5
#1Katerina Mastrocostas (Women's College Hospital)H-Index: 1
#2Sandra Fischer (TGH: Toronto General Hospital)H-Index: 25
Last. Tae Kyoung Kim (Women's College Hospital)H-Index: 63
view all 8 authors...
PURPOSE To assess the imaging findings of hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT) as a bridging therapy prior to liver transplantation (LT), with histopathological correlation at liver explant. METHODS Our institutional review board approved this retrospective study. The study subjects included 25 HCC lesions in 23 patients (20 males; median age, 60 years; range 41-68 years) who underwent LT after SBRT for HCC as a bridge to LT in a single tertiary ...
#1Andrews T (UHN: University Health Network)H-Index: 1
#2Jawairia Atif (U of T: University of Toronto)H-Index: 1
Last. Sonya A. MacParlandH-Index: 16
view all 20 authors...
The critical functions of the human liver are coordinated through the interactions of hepatic parenchymal and non-parenchymal cells. Recent advances in single cell transcriptional approaches have enabled an examination of the human liver with unprecedented resolution. However, dissociation related cell perturbation can limit the ability to fully capture the human livers parenchymal cell fraction, which limits the ability to comprehensively profile this organ. Here, we report the transcriptional ...
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