Bettina Hieronimus
University of California, Davis
Ligand (biochemistry)MonosaccharideAdipogenesisInternal medicineEndocrinologyAnimal science3T3-L1ChemistryPeroxisome proliferator-activated receptorYoung adultTransferrinEicosapentaenoic acidAdiponectinFructoseSugarDocosahexaenoic acidHigh-fructose corn syrupDyslipidemiaCholesterolPostprandialAspartameFerritinFree sugarSucroseTriglycerideDiseaseInsulinMEDLINEUric acidContext (language use)LipoproteinWeight gainMetabolic syndromeLeptinCeruloplasminBlood drawingApolipoprotein CIIILDL ParticlesFerroxidase activityInsulin secretionInsulin sensitivityEnergy requirementSmall dense ldlHepatic lipidLinear trendFood scienceObesityFatty acidBiochemistryDiabetes mellitusMetabolismApolipoprotein BMedicineArea under the curve
11Publications
4H-index
35Citations
Publications 11
Newest
#1Desiree M. Sigala (UC Davis: University of California, Davis)H-Index: 3
#2Bettina Hieronimus (UC Davis: University of California, Davis)H-Index: 4
Last. Abhijit J. Chaudhari (UC Davis: University of California, Davis)H-Index: 18
view all 19 authors...
CONTEXT Studies in rodents and humans suggest that high fructose corn syrup (HFCS)-sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets. OBJECTIVE To compare the effects of consuming sucrose-sweetened beverage (-SB), HFCS-SB, or a control beverage sweetened with aspartame on metabolic outcomes in humans. DESIGN A parallel, double-blinded, NIH-funded study. SETTING Experimental procedures were conducted during 3.5 days of inpatient residence with controlled feeding a...
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#1Bettina Hieronimus (UC Davis: University of California, Davis)H-Index: 4
#2Valentina Medici (UC Davis: University of California, Davis)H-Index: 31
Last. Kimber L. Stanhope (UC Davis: University of California, Davis)H-Index: 56
view all 9 authors...
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#1Desiree M. Sigala (UC Davis: University of California, Davis)H-Index: 3
#2Adrianne Widaman (SJSU: San Jose State University)H-Index: 5
Last. Nancy L. Keim (UC Davis: University of California, Davis)H-Index: 40
view all 11 authors...
Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (Δ) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (n = 131; BMI 18-35 kg/m2; 18-40 years) consumed three beverages/day containing aspartame or 25% energy requirement as glucose, fructose, high fructose corn syrup (HFCS) or sucrose (n = ...
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#1Bettina Hieronimus (UC Davis: University of California, Davis)H-Index: 4
#2Valentina Medici (UC Davis: University of California, Davis)H-Index: 31
Last. Kimber L. Stanhope (UC Davis: University of California, Davis)H-Index: 56
view all 9 authors...
BACKGROUND Fructose consumption increases risk factors for cardiometabolic disease. It is assumed that the effects of free sugars on risk factors are less potent because they contain less fructose. We compared the effects of consuming fructose, glucose or their combination, high fructose corn syrup (HFCS), on cardiometabolic risk factors. METHODS Adults (18-40 years; BMI 18-35 kg/m2) participated in a parallel, double-blinded dietary intervention during which beverages sweetened with aspartame, ...
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#2Bettina HieronimusH-Index: 4
Last. Valentina MediciH-Index: 31
view all 11 authors...
Alterations of transition metal levels have been associated with obesity, hepatic steatosis, and metabolic syndrome in humans. Studies in animals indicate an association between dietary sugars and copper metabolism. Our group has conducted a study in which young adults consumed beverages sweetened with glucose, fructose, high fructose corn syrup (HFCS), or aspartame for two weeks and has reported that consumption of both fructose- and HFCS-sweetened beverages increased cardiovascular disease ris...
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#1Desiree M. SigalaH-Index: 3
#2Bettina HieronimusH-Index: 4
Last. Kimber L. StanhopeH-Index: 56
view all 15 authors...
Rodent studies demonstrate that compared with diets sweetened with sucrose, high fructose corn syrup (HFCS) produces greater metabolic dysfunction. However, the effects of sustained consumption of HFCS and sucrose have not been adequately compared in humans. The objective of this study was to compare HFCS-, sucrose-, or aspartame- sweetened beverage (-SB) consumption on hepatic lipid content and insulin sensitivity in young adults. In a parallel, double-blinded study, adult men and women (18-40 ...
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#1Bettina Hieronimus (UC Davis: University of California, Davis)H-Index: 4
#2Kimber L. StanhopeH-Index: 56
PURPOSE OF REVIEW: Chronic consumption of fructose and fructose-containing sugars leads to dyslipidemia. Apolipoprotein (apo) CIII is strongly associated with elevated levels of triglycerides and cardiovascular disease risk. We reviewed the effects of fructose consumption on apoCIII levels and the role of apoCIII in fructose-induced dyslipidemia. RECENT FINDINGS: Consumption of fructose increases circulating apoCIII levels compared with glucose. The more marked effects of fructose compared with ...
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#1Bettina Hieronimus (UC Davis: University of California, Davis)H-Index: 4
#2Vivien Lee (UC Davis: University of California, Davis)H-Index: 4
Last. Kimber L. Stanhope (UC Davis: University of California, Davis)H-Index: 56
view all 5 authors...
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#1Bettina Hieronimus (UC Davis: University of California, Davis)H-Index: 4
#2Steven C. Griffen (UC Davis: University of California, Davis)H-Index: 16
Last. Kimber L. Stanhope (UC Davis: University of California, Davis)H-Index: 56
view all 8 authors...
ApoCIII and triglyceride (TG)-rich lipoproteins (TRL), particularly, large TG-rich lipoproteins particles, have been described as important mediators of cardiovascular disease (CVD) risk. The effects of sustained consumption of dietary fructose compared with those of sustained glucose consumption on circulating apoCIII and large TRL particles have not been reported. We measured apoCIII concentrations and the TG and cholesterol content of lipoprotein subfractions separated by size in fasting and ...
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#1Bettina HieronimusH-Index: 4
#2Valentina MediciH-Index: 31
Last. Kimber L. StanhopeH-Index: 56
view all 6 authors...
Global sugar consumption is at an all-time high. In previous studies, we and others have demonstrated that, compared with glucose (Gluc), consumption of fructose (Fruc) increases risk factors for cardiovascular disease (CVD), diabetes and metabolic syndrome. However, humans almost exclusively consume Fruc in combination with Gluc. Our aim was to study effects of Gluc, Fruc and their combination - high fructose corn syrup (HFCS) - and identify effects on metabolic risk factors. We performed a par...
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