Marta Vismara
University of Milan
Vascular endothelial growth factor COncologyCellStromal cellChemistryLymphangiogenesisPlatelet transfusionMetastasisTumor progressionLiquid biopsyTriple-negative breast cancerPopulationCancer-Associated FibroblastsSecretionCancer researchBreast cancerCirculating tumor cellFresh frozen plasmaMedicineBiology
13Publications
2H-index
38Citations
Publications 13
Newest
#1Marco SilvestriH-Index: 3
#2Carolina ReduzziH-Index: 6
Last. Vera CappellettiH-Index: 21
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Circulating tumor microemboli (CTMs) are clusters of cancer cells detached from solid tumors, whose study can reveal mechanisms underlying metastatization. As they frequently comprise unknown fractions of leukocytes, the analysis of copy number alterations (CNAs) is challenging. To address this, we titrated known numbers of leukocytes into cancer cells (MDA-MB-453 and MDA-MB-36, displaying high and low DNA content, respectively) generating tumor fractions from 0–100%. After low-pass sequencing, ...
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In biliary tract cancer (BTC), tissue biopsies to guide treatment are rarely feasible, thus implementing liquid biopsy approaches to improve patient management represents a priority. So far, studies on circulating tumor cells (CTCs) in BTC are insufficient to promote their use in patient clinical management and are limited to EpCAM-enriched CTCs evaluated with the CellSearch. We applied a single-cell protocol allowing identification not only of epithelial CTCs (eCTCs), but also of nonconventiona...
2 CitationsSource
#1S. Di CosimoH-Index: 15
#2Marco SilvestriH-Index: 3
Last. M. G. DaidoneH-Index: 2
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Circulating tumor cells (CTCs) are promising biomarkers for prognosis, therapeutic response prediction, and treatment monitoring in cancer patients. Despite its epithelial origin, renal cell carcinoma (RCC) shows low expression of epithelial markers hindering CTC-enrichment approaches exploiting epithelial cell surface proteins. In 21 blood samples serially collected from 10 patients with metastatic RCC entering the TARIBO trial, we overcame this limitation using the marker-independent Parsortix...
3 CitationsSource
#1Carolina ReduzziH-Index: 6
#2Marta VismaraH-Index: 2
Last. Vera CappellettiH-Index: 21
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Abstract The presence in the blood of patients with solid tumors of circulating cells expressing both epithelial and leukocyte markers (dual-positive cells, DPcells), has often been reported, though it has never been investigated in detail. A recent study suggested that DPcells are hybrid cells derived from the fusion of tumor cells with macrophages. Such fusion hybrids acquire macrophage-associated features endowing them with accelerated growth, increased motility, enhanced invasion activity an...
2 CitationsSource
In metastatic breast cancer the role of circulating tumor cells (CTCs) enumeration for predicting clinical outcome is supported by many studies, most of them dealing with strictly epithelial cells. However, it is becoming clear that CTCs are a heterogeneous cell population characterized by plasticity and including also cells which have lost the epithelial phenotype. Here we review literature data on CTC heterogeneity both at phenotype and at molecular level and discuss the possible contribute of...
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#1Carolina ReduzziH-Index: 6
#2Marta VismaraH-Index: 2
Last. Vera CappellettiH-Index: 21
view all 11 authors...
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#1Carolina ReduzziH-Index: 6
#2Marta VismaraH-Index: 2
Last. Vera CappellettiH-Index: 21
view all 12 authors...
e15637Background: In cholangiocarcinoma (CCA), molecular analysis during disease progression is rarely feasible due to low access to tissue. Circulating tumor cells (CTCs) could overcome this issue...
1 CitationsSource
#1Massimiliano Cadamuro (UNIPD: University of Padua)H-Index: 23
#2Simone Brivio (University of Milan)H-Index: 9
Last. Luca Fabris (Yale University)H-Index: 34
view all 19 authors...
Background & Aims In cholangiocarcinoma, early metastatic spread via lymphatic vessels often precludes curative therapies. Cholangiocarcinoma invasiveness is fostered by an extensive stromal reaction, enriched in cancer-associated fibroblasts (CAFs) and lymphatic endothelial cells (LECs). Cholangiocarcinoma cells recruit and activate CAFs by secreting PDGF-D. Herein, we investigated the role of PDGF-D and liver myofibroblasts in promoting lymphangiogenesis in cholangiocarcinoma. Methods Human ch...
26 CitationsSource
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