Ketevani Kankava
Tbilisi State Medical University
Internal medicineEndocrinologyPathologyOncologyPediatricsHuman leukocyte antigenImmunohistochemistryYoung adultHazard ratioImmunotherapyKi-67Large cellMEDLINELymphContext (language use)Differential diagnosisLymph nodeCD44AdenocarcinomaKRASMitotic CountProliferation indexNeuroendocrine CarcinomasMolecular analysisAdult agePrognostic factorGene mutationGastro entero pancreaticLabeling indexMesenteric tumorPersonalized treatmentNomogramConfidence intervalProportional hazards modelHistologyMedicineBiologyImmune systemGastroenterology
6Publications
3H-index
27Citations
Publications 12
Newest
#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Patrick Maisonneuve (IEO: European Institute of Oncology)H-Index: 134
Last. Stefano Di DomenicoH-Index: 9
view all 15 authors...
Updates in classification of gastro-entero-pancreatic neuroendocrine neoplasms better reflect the biological characteristics of these tumours. In the present study, we analysed the characteristics of neuroendocrine tumours that could aid in a more precise stratification of risk groups. In addition, we have highlighted the importance of grade (re)assessment based on investigation of secondary tumour lesions. Two hundred and sixty-four cases of neuroendocrine tumours of gastro-entero-pancreatic or...
Source
#1Massimo MilioneH-Index: 31
#2Patrick MaisonneuveH-Index: 134
Last. Carlo CapellaH-Index: 89
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BACKGROUND: Little information is available concerning prognostic factors of bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical and molecular approach could be used for their prognostic evaluation. METHODS: Morphological (including combined features), proliferative (mitotic count/Ki-67 index), immunohistochemical (napsin A, p-40, TTF-1, CD44, OTP, SSTR...
5 CitationsSource
#1Ketevani KankavaH-Index: 3
#2Patrick MaisonneuveH-Index: 134
view all 15 authors...
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#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Kvaratskhelia E (Tbilisi State Medical University)H-Index: 4
Last. E. Abzianidze (Tbilisi State Medical University)H-Index: 4
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Abstract null null The role of genetic predisposition in cancer pathogenesis is well known. Despite the fact that in many cases exact mechanisms cannot be understood, overall observational and experimental data confirm the role of hereditary factors in cancer development and progression. Gynecologic cancers are not an exception. Increased risk for these tumors in the families of affected individuals lead to intensive research aggravated by huge data from GWAS. It seems like an insight into genet...
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#1Adele BusicoH-Index: 16
#2Patrick MaisonneuveH-Index: 134
Last. Massimo MilioneH-Index: 31
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Background: In gastroenteropancreatic (GEP) high-grade neuroendocrine neoplasms (H-NENs), Ki-67 threshold of 55%, instead of 20%, defines three prognosis subclasses: neuroendocrine tumor (NET) G3, neuroendocrine carcinoma (NEC) <55% and NEC ≥55%. We investigated whether the molecular profiling of H-NENs differ among these sub-categories and evaluated potential therapeutic targets, including PD-L1. Methods: In consecutive GEP-NEN patients we evaluated: i) 55% threshold for Ki-67 labelling index f...
12 CitationsSource
#1Giovanni CentonzeH-Index: 11
#2Alessandro Mangogna (Health Science University)H-Index: 8
Last. Massimo MilioneH-Index: 31
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Gastroblastoma (GB) is a rare gastric epithelial-mesenchymal neoplasm, first described by Miettinen et al. So far, all reported cases described the tumor in children or young adults, and similarities with other childhood blastomas have been postulated. We report a case of GB in a 43-year-old patient with long follow up and no recurrence up to 100 months after surgery. So far, this is the second case of GB occurring in the adult age >40-year-old. Hence, GB should be considered in the differential...
2 CitationsSource
#1Massimo MilioneH-Index: 31
#2Rosalba MiceliH-Index: 63
Last. Andrea AnichiniH-Index: 62
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: Microenvironment-related immune and inflammatory markers, when combined with established Ki-67 and morphology parameters, can improve prognostic prediction in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs). Therefore, we evaluated the prognostic value of microenvironment and tumor inflammatory features (MoTIFs) in GEP-NENs. For this purpose, formalin-fixed paraffin-embedded tissue sections from 350 patients were profiled by immunohistochemistry for immune, inflammatory, angiogene...
12 CitationsSource
#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Kvaratskhelia E (Tbilisi State Medical University)H-Index: 4
Last. E. Abzianidze (Tbilisi State Medical University)H-Index: 4
view all 7 authors...
Epigenetic changes in breast cancer patients have long been believed to be a promising marker for clinical management - early detection, prognostication, etc. Various approaches are available to test global DNA or target gene methylation status. We used some of them in different tissues of patients with breast cancer to analyze possible links between epigenetic parameters and their value for predicting clinicopathological characteristics (most importantly stage and lymph node status) of tumors. ...
#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Kvaratskhelia EH-Index: 4
Last. E. AbzianidzeH-Index: 4
view all 6 authors...
Methylation is an epigenetic alteration proved to be involved in many disease processes including cancer. This change affects mainly gene promoters and repetitive sequences in genome. Long Interspersed Nuclear Element-1 (LINE-1) is a family of retrotransposons - repetitive elements that modify gene activity and can themselves be targeted by epigenetic mechanisms. LINE-1 methylation level is a surrogate marker for global methylation. In many conditions this parameter is found to be altered not on...
3 Citations
#1Kvaratskhelia T (Tbilisi State Medical University)
#2Kvaratskhelia E (Tbilisi State Medical University)H-Index: 4
Last. E. Abzianidze (Tbilisi State Medical University)H-Index: 4
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: The aim of our study was to investigate the link between MTHFR gene C677T polymorphism and DNMTs levels in patients with Subclinical Hypothyroidism (SCH). In this study 19 adult patients with subclinical hypothyroidism and 19 healthy controls (mean age 31±5.5 and 33±5.1 years respectively) were recruited. All patients were diagnosed based on serum levels of TSH, FT4, anti-TG and anti-TPO antibodies. Written informed consents were obtained from all study subjects. Genomic DNA was extracted usin...
1 Citations