Leah Cicon
University of Victoria
Colloidal goldCancerBiophysicsDNA damageCellNanomedicineNanoparticleRegulation of gene expressionStromal cellChemistryIn vitroMicrotubuleTumor microenvironmentChemotherapyHeLaNucleusDocetaxelDrug synergismCancer-Associated FibroblastsMetal nanoparticlesNormal tissue toxicityCancer researchRadiation therapyIntracellularCell cultureCancer cellDistribution (pharmacology)
5Publications
3H-index
20Citations
Publications 5
Newest
#1Kyle Bromma (UVic: University of Victoria)H-Index: 7
#2Aaron Bannister (UVic: University of Victoria)H-Index: 3
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 5 authors...
Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on cancer cells, but FBs and CAFs also play a critical role: FBs suppress the tumor growth while CAFs promote it. It is not yet known how NPs interact wit...
2 CitationsSource
#1Kyle Bromma (UVic: University of Victoria)H-Index: 7
#2Leah Cicon (UVic: University of Victoria)H-Index: 3
Last. Devika B. ChithraniH-Index: 17
view all 4 authors...
One of the major issues in cancer radiotherapy (RT) is normal tissue toxicity. Introduction of radiosensitizers like gold nanoparticles (GNPs) into cancer cells to enhance the local RT dose has been tested successfully. However, it is not known how GNPs interact with other stromal cells such as normal fibroblasts (FBs) and cancer associated fibroblasts (CAFs) within the tumour microenvironment. It is known that FBs turn into CAFs to promote tumour growth. Hence, we used FBs and CAFs along with H...
5 CitationsSource
#1Aaron Bannister (UVic: University of Victoria)H-Index: 3
#2Dushanthi Dissanayake (UVic: University of Victoria)H-Index: 1
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 17
view all 6 authors...
Nanoparticles (NPs) have shown promise in both radiotherapy and chemotherapy. NPs are mainly transported along cellular microtubules (MTs). Docetaxel (DTX) is a commonly used chemotherapeutic drug that can manipulate the cellular MT network to maximize its clinical benefit. However, the effect of DTX on NP behaviour has not yet been fully elucidated. We used gold NPs of diameters 15 and 50 nm at a concentration of 0.2 nM to investigate the size dependence of NP behaviour. Meanwhile, DTX concentr...
1 CitationsSource
#1Aaron Bannister (UVic: University of Victoria)H-Index: 3
#2Kyle Bromma (UVic: University of Victoria)H-Index: 7
Last. Devika B. ChithraniH-Index: 17
view all 9 authors...
Objective:One of the major issues in current radiotherapy (RT) is the normal tissue toxicity. A smart combination of agents within the tumor would allow lowering the RT dose required while minimizi...
8 CitationsSource
#1Kyle BrommaH-Index: 7
#2Leah CiconH-Index: 3
Last. B. D. ChithraniH-Index: 2
view all 6 authors...
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