Alexandra Libby
Princeton University
PromoterTransformation (function)PhosphorylationEncoding (memory)Dimension (vector space)Stimulus (physiology)Interference (wave propagation)NeuroscienceCognitionKinaseChemistryRepresentation (systemics)Implicit learningAuditory cortexPopulationKinase activityComputer scienceRegulonNeural codingTranscription factorSensory systemCell biologyProtein kinase A
Publications 2
#1Christine R. Zheng (Wyss Institute for Biologically Inspired Engineering)
#1Christine R. Zheng (Wyss Institute for Biologically Inspired Engineering)H-Index: 3
Last. Elizabeth A. Libby (Wyss Institute for Biologically Inspired Engineering)H-Index: 6
view all 5 authors...
A lack of direct single-cell readouts for bacterial kinase activity remains a major barrier to our understanding of most signaling systems. At the single-cell-level, protein kinase activity is typically inferred by the activity of downstream transcriptional reporters. Complicating this approach in vivo, promoters are often co-regulated by several pathways, making the activity of a specific kinase difficult to deconvolve. Here, we have designed and constructed new, direct and specific sensors of ...
#1Alexandra Libby (Princeton University)H-Index: 2
#2Timothy J. Buschman (Princeton University)H-Index: 20
Cognition depends on integrating sensory percepts with the memory of recent stimuli. However, the distributed nature of neural coding can lead to interference between sensory and memory representations. Here, we show that the brain mitigates such interference by rotating sensory representations into orthogonal memory representations over time. To study how sensory inputs and memories are represented, we recorded neurons from the auditory cortex of mice as they implicitly learned sequences of sou...
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