Vashti S. Knight
University of California, San Diego
NeuropeptideInternal medicineEndocrinologyCarbohydrate metabolismGene knockdownChemistryGonadotropic cellGlycolysisStimulationGNRHRHypothalamusAndrogenGLUT1Luteinizing hormoneGonadotropinAnterior pituitaryFSHBSecretionHormoneBiologyProtein kinase A
4Publications
1H-index
5Citations
Publications 4
Newest
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. Knight (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression in a pituitary gonadotrope cell model and in primary gonadotropes, we show GLUT1-dependent stimulation of glycolysis, but not mitochondrial respiration, by the reproductive neuropeptide GnRH. GnRH stimulation increases gonadotrope GLUT1...
Source
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. KnightH-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
Source
#1Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
#2Danmei Li (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
: A defining characteristic of the hypothalamus-pituitary-gonad reproductive endocrine axis is the episodic secretion of the pituitary gonadotropin hormones LH and FSH by the anterior pituitary gonadotropes. Hormone secretion is dictated by pulsatile stimulation, with GnRH released by hypothalamic neurons that bind and activate the G protein-coupled GnRH receptor expressed by gonadotropes. Hormone secretion and synthesis of gonadotropins are influenced by the amplitude and frequency of GnRH stim...
5 CitationsSource
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. Knight (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
Source