Eduard Roussel
Katholieke Universiteit Leuven
Interquartile rangeCancerInternal medicineRadiologyUrologySurgeryOncologyHazard ratioPathologicalPenile cancerRenal cell carcinomaMetastasisNephrectomyAngiogenesisKidney cancerClear cell renal cell carcinomaIn patientCytoreductive nephrectomyPerioperativeCancer researchMedicineCohort
45Publications
3H-index
35Citations
Publications 52
Newest
#1Lee A. HugarH-Index: 6
Last. Juan ChipolliniH-Index: 12
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#1Eduard Roussel (Katholieke Universiteit Leuven)H-Index: 3
#2Lisa Kinget (Katholieke Universiteit Leuven)
Last. Hendrik Van Poppel (Katholieke Universiteit Leuven)H-Index: 82
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BACKGROUND Glandular metastases (GM) have been associated with improved survival in metastatic clear cell renal cell carcinoma (m-ccRCC). We aimed to molecularly characterize m-ccRCC with GM. MATERIAL AND METHODS We performed a retrospective cohort study on all m-ccRCC patients with available tissue at our institution, diagnosed with metastatic disease from 2000 to 2019. We determined previously described angiogenesis- and immune-related gene expression signatures (GES) and ccrcc molecular subty...
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#1Lisa Kinget (Katholieke Universiteit Leuven)
#2Oliver Bechter (Katholieke Universiteit Leuven)H-Index: 14
Last. Marcella Baldewijns (Katholieke Universiteit Leuven)H-Index: 3
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In recent years, immune checkpoint inhibitors (ICPI) have become widely used for multiple solid malignancies. Reliable predictive biomarkers for selection of patients who would benefit most are lacking. Several tumor types with somatic or germline alterations in genes involved in the DNA damage response (DDR) pathway harbor a higher tumor mutational burden, possibly associated with an increased tumoral neoantigen load. These neoantigens are thought to lead to stronger immune activation and enhan...
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#2Hielke M. de Vries (NKI-AVL: Netherlands Cancer Institute)H-Index: 2
Last. Dingwei Ye (Fudan University)H-Index: 29
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Abstract null null Objective null A lack of demonstrated clinical benefit precludes radiotherapy (RT) from being recommended for pN1/pN2 penile cancer (PeCa) lesions; but it may be recommended in case of extranodal (pN3) disease or for positive resection margins. Perineal urethrostomy (PU) is a technique of urinary diversion in patients with PeCa requiring total or subtotal penectomy as primary therapy. Prior studies suggest PU failure rates of up to 30%, without specific mention of the potentia...
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#1Eduard Roussel (Katholieke Universiteit Leuven)H-Index: 3
#2Benoit Beuselinck (Katholieke Universiteit Leuven)H-Index: 25
Last. Maarten Albersen (Katholieke Universiteit Leuven)H-Index: 26
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Take Home Message null null Cytoreductive nephrectomy makes way for more effective systemic treatments in the current mRCC treatment paradigm, as disease volume and the number of IMDC risk factors increase. Careful patient selection for upfront or deferred cytoreductive nephrectomy based on these criteria remains key.
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#1Eduard Roussel (Katholieke Universiteit Leuven)H-Index: 3
#2Annelies Verbiest (Katholieke Universiteit Leuven)H-Index: 7
Last. Liesbeth De Wever (Katholieke Universiteit Leuven)H-Index: 10
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Abstract null null MicroAbstract null : Trials with adjuvant anti-angiogenic therapy failed to demonstrate significant benefit in high-risk, resected clear-cell renal cell carcinoma. We show that molecular subtypes and angiogenesis-related gene expression are associated with disease-free and overall survival. Clinically high-risk tumors are infrequently angiogenic but can display either high or low immunogenic gene expression. Molecular characterization could therefore better guide patient selec...
1 CitationsSource
#1Lisa Kinget (Katholieke Universiteit Leuven)
#2Eduard Roussel (Katholieke Universiteit Leuven)H-Index: 3
Last. Sylvie JobH-Index: 14
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Metastatic clear-cell renal cell carcinoma (m-ccRCC) is characterized by increased hypoxia-induced factor (HIF)-2α and vascular endothelial growth factor receptor (VEGFR)-dependent angiogenesis through loss of function of the von Hippel–Lindau protein. VEGFR tyrosine kinase inhibitors (VEGFR-TKIs) are a cornerstone of m-ccRCC treatment, and new treatments targeting HIF-2α are currently under investigation. However, predictive biomarkers for these treatments are lacking. In this retrospective coh...
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#1Hielke M. de Vries (NKI-AVL: Netherlands Cancer Institute)H-Index: 2
#2Juan Chipollini (UA: University of Arizona)H-Index: 12
Last. Viraj A. Master (Emory University)H-Index: 42
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Abstract null null Purpose null Perineal urethrostomy (PU) is often the definitive form of urinary diversion in patients with locally-advanced or anatomically unfavorable penile cancer (PC) requiring total penectomy. Here, we report post-operative PU-related complications and PU stenosis rates after total penectomy with PU in a large multicenter cohort of PC patients. null null null Methods null We retrospectively reviewed the medical records of 299 patients who underwent PU as a means of urinar...
1 CitationsSource