Marilena Rega
University College London
Imaging phantomCorrelationBiomedical engineeringPathologyMagnetic resonance imagingDiffusion MRIRepeatabilityNeuroscienceChemistryField strengthMaterials scienceRadiation treatment planningImmunologyIn vivoT cellProstateImmunodeficiencyTauopathyMagnetic resonance angiographyGliomaDigital subtraction angiographyCerebral angiographyAutoimmune diseaseDiseaseImmunityDementiaProstate cancerRadiosurgeryWhite matterMagnetization transferExtracellularSignal Sensitivity18F-cholineFor Attenuation CorrectionPreclinical imagingNuclear medicineGlucose infusionSaturation transferChemical exchangeCalcium fluxGamma knife radiosurgeryBody regionPet scannerComputational physicsGold standard (test)Computer sciencePercentage pointSpectral lineAlzheimer's diseaseCancer researchImage qualityGadoliniumEngineering physicsStatistical significanceMedicinePulse (signal processing)IntracellularImmune systemCoefficient of variation
Publications 10
#1Alvaro Rojas-Villabona (RVI: Royal Victoria Infirmary)H-Index: 3
#2Magdalena Sokolska (UCL: University College London)H-Index: 13
Last. Hans Rolf Jäger (UCL: University College London)H-Index: 47
view all 18 authors...
Purpose Intra-arterial Digital Subtraction Angiography (DSA) is the gold standard technique for radiosurgery target delineation in brain Arterio-Venous Malformations (AVMs). This study aims to evaluate whether a combination of three Magnetic Resonance Angiography sequences (triple-MRA) could be used for delineation of brain AVMs for Gamma Knife Radiosurgery (GKR). Methods Fifteen patients undergoing DSA for GKR targeting of brain AVMs also underwent triple-MRA: 4D Arterial Spin Labelling based a...
1 CitationsSource
#1Rhys Evans (UCL: University College London)H-Index: 11
#2Marilina Antonelou (UCL: University College London)H-Index: 4
Last. Alan D. Salama (UCL: University College London)H-Index: 57
view all 11 authors...
Increased extracellular sodium activates Th17 cells, which provide protection from bacterial and fungal infections. Whilst high salt diets have been shown to worsen autoimmune disease, the immunological consequences of clinical salt depletion are unknown. Here, we investigate immunity in patients with inherited salt-losing tubulopathies (SLT). Forty-seven genotyped SLT patients (with Bartter, Gitelman or EAST Syndromes) are recruited. Clinical features of dysregulated immunity are recorded with ...
4 CitationsSource
#1Mina Kim (UCL: University College London)H-Index: 3
#2F Torrealdea (UCLH: University College Hospital)H-Index: 1
Last. Xavier GolayH-Index: 60
view all 21 authors...
Background: The aim of this study was to translate dynamic glucose enhancement (DGE) body magnetic resonance imaging (MRI) based on the glucose chemical exchange saturation transfer (glucoCEST) signal to a 3 T clinical field strength. Methods: An infusion protocol for intravenous (i.v.) glucose was optimised using a hyperglycaemic clamp to maximise the chances of detecting exchange-sensitive MRI signal. Numerical simulations were performed to define the optimum parameters for glucoCEST measureme...
8 CitationsSource
#1Georgios Krokos ('KCL': King's College London)
#2J.E. Mackewn ('KCL': King's College London)H-Index: 9
Last. Julian C. Matthews (University of Manchester)H-Index: 26
view all 16 authors...
Standardisation of PET scanners participating in multicentre trials is important in achieving reliable results and in maximizing the power of the study. The first multicentre clinical trial studies involving seven PET-MR scanners in the UK (four GE SIGNA and three Siemens mMR) are underway, led by Dementias Platform UK. In this study, the qualification of the seven scanners was tested using the NEMA image quality phantom. Consistent scanning methodology was followed across all sites with a 5:1 s...
#1Vincent Evans (UCL: University College London)H-Index: 2
#2F. J. Torrealdea (UCL: University College London)H-Index: 9
Last. David Atkinson (UCL: University College London)H-Index: 68
view all 11 authors...
BACKGROUND: Chemical exchange saturation transfer (CEST) can potentially support cancer imaging with metabolically derived information. Multiparametric prostate MRI has improved diagnosis but may benefit from additional information to reduce the need for biopsies. PURPOSE: To optimize an acquisition and postprocessing protocol for 3.0 T multipool CEST analysis of prostate data and evaluate the repeatability of the technique. STUDY TYPE: Prospective. SUBJECTS: Five healthy volunteers (age range: ...
8 CitationsSource
#1Francesco Fraioli (UCL: University College London)H-Index: 23
#2Ananth Shankar (UCL: University College London)H-Index: 3
Last. Anna Barnes (UCL: University College London)H-Index: 12
view all 9 authors...
#1F TorrealdeaH-Index: 1
Last. Marilena RegaH-Index: 4
view all 11 authors...
#1Marilena RegaH-Index: 4
#2F TorrealdeaH-Index: 1
Last. Harpreet HyareH-Index: 18
view all 11 authors...
#2F TorrealdeaH-Index: 1
Last. David AtkinsonH-Index: 68
view all 6 authors...
#1Jack A. Wells (UCL: University College London)H-Index: 20
#2James M. O'Callaghan (UCL: University College London)H-Index: 11
Last. Mark F. Lythgoe (UCL: University College London)H-Index: 55
view all 22 authors...
As the number of people diagnosed with Alzheimer's disease (AD) reaches epidemic proportions, there is an urgent need to develop effective treatment strategies to tackle the social and economic costs of this fatal condition. Dozens of candidate therapeutics are currently being tested in clinical trials, and compounds targeting the aberrant accumulation of tau proteins into neurofibrillary tangles (NFTs) are the focus of substantial current interest. Reliable, translatable biomarkers sensitive to...
48 CitationsSource